ACTG2 Antibody, HRP conjugated

說明書

中文名稱：

ACTG2兔多克隆抗體, HRP偶聯
貨號：

CSB-PA12799B0Rb
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ACTG2 Polyclonal antibody
Uniprot No.：

P63267
基因名：

ACTG2
別名：

ACT antibody; ACTA3 antibody; ACTE antibody; ACTG2 antibody; ACTH_HUMAN antibody; Actin antibody; Actin gamma 2 smooth muscle enteric antibody; Actin gamma enteric smooth muscle antibody; Actin like protein antibody; ACTL3 antibody; ACTSG antibody; Alpha actin 3 antibody; Alpha-actin-3 antibody; Gamma 2 actin antibody; Gamma-2-actin antibody; gamma-enteric smooth muscle antibody; Smooth muscle gamma actin antibody; Smooth muscle gamma-actin antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Actin, gamma-enteric smooth muscle protein (181-376AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
基因功能參考文獻：
1. fetus with intestinal pseudo-obstruction heterozygous for p.R63G pathogenic variant (NM_001615.3 c.187C>G; rs864309491) in exon 3 PMID: 29072330
2. Whole exome and Sanger sequencing revealed a pathogenic variant in the ACTG2 gene in 4 out of 28 probands with chronic intestinal pseudo-obstruction and megacystis. Moreover, a mutational hotspot in the ACTG2 gene was recognized. Genetic heterogeneity is evident. PMID: 28422808
3. R257 variant in the ACTG2 appear to be more frequent in populations of Asian ancestry; mutation of this locus could cause alterations of the intestinal and bladder smooth muscle filaments. PMID: 27007401
4. ACTG2 boosts the metastatic potential of hepatocellular carcinoma in a Notch1-dependent manner. PMID: 28385530
5. Missense variants in ACTG2 were identified in the patients with either megacystis-microcolon-intestinal hypoperistalsis syndrome or intestinal pseudo-obstruction. PMID: 26813947
6. A heterozygous missense variant in ACTG2 was identified that impaired actin polymerization in sporadic Megacystis microcolon intestinal hypoperistalsis syndrome. PMID: 26647307
7. ACTG2 is expressed in a fraction of small intestinal neuroendocrine tumors, can inhibit cell growth in vitro, and is positively regulated by miR-145. PMID: 27107594
8. Mutations within ACTG2 are associated with fetal megacystis in microcolon intestinal hypoperistalsis syndrome. PMID: 25998219
9. Phenotypic spectrum of ACTG2 missense variants involved severe pathology in multiple smooth muscle-dependent organs including the biliary tract and the uterus in the family with visceral myopathy. PMID: 25782675
10. gammaSMA expression in hepatocellular carcinoma is strongly correlated with the EMT process, HCC aggressiveness and the identification of cancer stem cells PMID: 26110787
11. ACTG2 encodes g2 enteric actin and is the first gene to be clearly associated with Megacystis-microcolon-intestinal hypoperistalsis syndrome, suggesting an important role for contractile proteins in enteric smooth muscle disease. PMID: 24676022
12. Two novel mutations in the ACTG2 gene, p.R178L and p.R178C, have been identified in two unrelated children with congenital distended bladder, microcolon, and intestinal hypoperistalsis (MMIHS). PMID: 24337657
13. The R148S variant in ACTG2 as a cause of autosomal dominant familial visceral myopathy in one family. PMID: 22960657
14. NOX4 and ROS have a role in myofibroblast differentiation and collagen and alpha-actin production of TGF- beta1-induced nasal polyp-derived fibroblasts. PMID: 22722757
15. SMGA gene activity in prostate epithelia is due, in part, to the androgen-dependent expression of Nkx 3.1 PMID: 12450213
16. It was suggested that peritubular alphaSMA-positive myofibroblastic cells, in collaboration with interstitial macrophages, contribute to the progression of interstitial fibrosis in diabetic nephropathy. PMID: 17009076
17. TNF-alpha suppresses TGF-beta1-induced myofibroblast (fibroproliferative) phenotypic genes, for example, alpha-SMA, collagen type 1A, and fibronectin at the mRNA level. PMID: 17554369
18. The insertion-deletion polymorphism in intron 1 of the gamma 2 actin gene is unlikely to play any significant role in obstetric cholestasis or preeclampsia in patients from eastern Finland. PMID: 17934296
19. MYOCD can discriminate among several juxtaposed CArG elements, presumably through its novel partnership with NKX3.1, to optimally transactivate the human ACTG2 promoter PMID: 19797053
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相關疾病：

Visceral myopathy (VSCM)
亞細胞定位：

Cytoplasm, cytoskeleton.
蛋白家族：

Actin family
數據庫鏈接：

HGNC: 145

OMIM: 102545

KEGG: hsa:72

STRING: 9606.ENSP00000295137

UniGene: Hs.516105

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