TUBB2A Monoclonal Antibody
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中文名稱：TUBB2A鼠單克隆抗體
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貨號：CSB-MA000312
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規(guī)格：￥1090
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圖片：
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1) Input: Mouse Brain Tissue Lysate 2) IP product: IP dilute 1: 200 Western blot analysis: primary antibody : 1: 10000 Secondary antibody: Goat anti-Mouse IgG, Light chain specific (S003), 1: 5000 -
Western blot analysis of 1) Mouse Brain tissue, 2) Rat Brain tissue, diluted at 1:100000.
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：CUSABIO貨號：CSB-MA000312 TUBB2A單克隆抗體靶向β-微管蛋白2A（TUBB2A），該蛋白作為細(xì)胞骨架核心成分參與細(xì)胞形態(tài)維持、胞內(nèi)運(yùn)輸及有絲分裂等重要生物學(xué)過程，在神經(jīng)發(fā)育和腫瘤微環(huán)境調(diào)控等領(lǐng)域具有重要研究價(jià)值。本產(chǎn)品采用雜交瘤技術(shù)制備，經(jīng)ELISA、Western Blot和免疫沉淀（IP）嚴(yán)格驗(yàn)證，可特異性識別小鼠、大鼠及人源樣本中的TUBB2A蛋白，適用于微管蛋白復(fù)合物分析、細(xì)胞周期研究及神經(jīng)退行性疾病模型構(gòu)建等科研場景。該抗體具備高親和力與特異性，為探索細(xì)胞骨架動態(tài)調(diào)控機(jī)制、神經(jīng)元分化路徑及微管相關(guān)蛋白互作網(wǎng)絡(luò)提供可靠工具，助力細(xì)胞生物學(xué)、神經(jīng)科學(xué)及腫瘤微管靶向治療等前沿領(lǐng)域的研究突破。
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Uniprot No.：
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基因名：
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別名：TUBB2A antibody; TUBB2 antibody; Tubulin beta-2A chain antibody; Tubulin beta class IIa antibody
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宿主：Mouse
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反應(yīng)種屬：Mouse,Rat,Human
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免疫原：Synthetic Peptide
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免疫原種屬：M, R, (H)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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克隆號：28B6
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IP
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IP 1:200-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
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基因功能參考文獻(xiàn)：
- TUBB2A missense mutation is associated with arthrogryposis multiplex congenita, brain abnormalities, and severe developmental delay. PMID: 28840640
- study associates mutations in TUBB2A with the spectrum of "tubulinopathy" phenotypes PMID: 24702957
- This is the first study showing that paclitaxel neuropathy risk is influenced by polymorphisms regulating the expression of a beta-tubulin gene. PMID: 22718863
- Class II beta-tubulin may be very useful for immunohistochemical diagnosis of classical Hodgkin's lymphoma. PMID: 22449234
- Data suggest that the increased betaII- and betaIII-tubulin contributed significantly to the resistance phenotype. PMID: 22180309
- lack of mutations in early stage lung cancer PMID: 12209967
- Mutations of the beta-tubulin gene, which might be a contraindication for chemotherapy based on taxans, were very rare events in gastric cancer. PMID: 12861402
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相關(guān)疾病：Cortical dysplasia, complex, with other brain malformations 5 (CDCBM5)
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亞細(xì)胞定位：Cytoplasm, cytoskeleton.
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蛋白家族：Tubulin family
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組織特異性：High expression in brain, where it represents 30% of all beta-tubulins.
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數(shù)據(jù)庫鏈接：
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