TUBB1 Monoclonal Antibody

說明書

中文名稱：

TUBB1鼠單克隆抗體
貨號：

CSB-MA000278
規格：

￥1090
圖片：
Western blot analysis of Zebrafish skeletal muscle, diluted at 1:5000.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

CUSABIO貨號：CSB-MA000278單克隆抗體是針對斑馬魚TUBB1靶點研發的科研專用試劑，適用于免疫印跡和酶聯免疫吸附實驗。TUBB1作為β-微管蛋白家族成員，在細胞骨架構成、有絲分裂調控及細胞形態維持中發揮關鍵作用，是研究細胞周期動態和細胞極性機制的重要分子標記物。該產品采用重組蛋白免疫技術制備，具備高親和力和特異性，經過嚴格驗證可精準識別斑馬魚模型中的TUBB1蛋白，為發育生物學、神經軸突導向研究和細胞遷移實驗提供可靠工具，尤其適用于胚胎發育階段的微管網絡可視化分析和基因功能驗證。通過優化抗體反應體系，可在斑馬魚組織裂解液中實現清晰的蛋白條帶檢測，滿足細胞骨架動態監測、基因敲除效果評估等基礎科研需求，為探索微管相關疾病機制提供有效研究手段。
Uniprot No.：

Q9H4B7
基因名：

TUBB1
別名：

2810484G07Rik antibody; beta 1 tubulin antibody; Beta tubulin 1, class VI antibody; Beta-tubulin antibody; Class VI beta tubulin antibody; dJ543J19.4 antibody; M(beta)1 antibody; TBB1_HUMAN antibody; TUBB1 antibody; Tubulin beta 1 class VI antibody; Tubulin beta-1 chain antibody; Tubulin, beta 1 antibody; tubulin, beta1 antibody
宿主：

Mouse
反應種屬：

Zebrafish
免疫原：

Synthetic Peptide
免疫原種屬：

Danio rerio (Zebrafish) (Brachydanio rerio)
標記方式：

Non-conjugated
抗體亞型：

IgG
克隆號：

8H4
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
基因功能參考文獻：
1. Neonatal platelets exhibit low levels of the Stx11-Munc18b complex (essential component of the SNARE machinery) and of beta1-tubulin. These developmental deficiencies are associated with defects in platelet adhesion, spreading and secretion. PMID: 29044293
2. novel DCX mutation (p.D90G, NP_000546.2) appeared to be a major causative variant, whereas the novel mutation of TUBB1 (p.R62fsX, NP_110400.1) was found only in patients with more-severe intellectual disability in Familial pachygyria PMID: 26743950
3. Analysis of the TUBB1 gene revealed three known missense variants in heterozygous state which in combination might explain the beta1-tubulin defect. PMID: 26540125
4. TUBB1 R307H SNP is significantly associated with the degree of thrombocytopenia in congenital and acquired platelet disorders, and may affect platelets by altering microtubule behavior. PMID: 25529050
5. Data indicate that ABCB1 protein, beta tubulin I and III (betaI, and betaIII tubulin) might contribute to the multidrug resistance (MDR) of MCF7/DOC and be potential therapeutic targets for overcoming MDR of breast cancer. PMID: 24894670
6. TUBB1 mutation disrupting microtubule assembly impairs proplatelet formation and results in congenital macrothrombocytopenia. PMID: 24344610
7. our findings define beta-tubulin VI as a hematologic isotype with significant genetic variation in humans that may affect the myelosuppresive action of microtubule-binding drugs PMID: 22805305
8. homozygous status of P43 genetic polymorphism causes alterations in platelet ultrastructure PMID: 21384078
9. Studies show that BFBTS bound and modified beta-tubulin at residue Cys12, forming beta-tubulin-SS-fluorobenzyl. PMID: 19996274
10. SLPI localizes in part along the megakaaryocyte and platelet cytoskeleton by virtue of specific interactions with beta1 tubulin. PMID: 15315966
11. the platelet Q43P beta1-tubulin substitution is frequent in the healthy population and may protect men against arterial thrombosis PMID: 15956286
12. The TUBB1 Q43P polymorphism, by causing a lower reactivity in platelets carrying the variant form of b1-tubulin, protects against thrombotic disorders but increases the risk of intracerebral hemorrhage in men. PMID: 17488662
13. biophysical analysis of carboxy-terminal tail conformation of human beta-tubulin isotypes PMID: 17993481
14. Mutation of the beta1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly. PMID: 18849486
15. TUBB1 Q43P polymorphism does not protect against acute coronary syndrome and premature myocardial infarction. PMID: 19132255
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相關疾病：

Macrothrombocytopenia, autosomal dominant, TUBB1-related (MAD-TUBB1)
亞細胞定位：

Cytoplasm, cytoskeleton.
蛋白家族：

Tubulin family
組織特異性：

Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins.
數據庫鏈接：

HGNC: 16257

OMIM: 612901

KEGG: hsa:81027

STRING: 9606.ENSP00000217133

UniGene: Hs.303023

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