TUBB1 Monoclonal Antibody

說明書

中文名稱：

TUBB1鼠單克隆抗體
貨號：

CSB-MA000192
規(guī)格：

￥1090
圖片：
Western blot analysis of 1) Hela, 2) Mouse Brain Tissue, 3) Rat Brain Tissue, diluted at 1:5000.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品描述：

CUSABIO貨號：CSB-MA000192 TUBB1單克隆抗體是針對β-微管蛋白家族成員TUBB1研發(fā)的特異性檢測工具，該靶點在血小板形成過程中發(fā)揮關(guān)鍵作用，參與調(diào)控巨核細(xì)胞分化和血小板釋放機制，其表達(dá)異常與血小板減少癥等血液系統(tǒng)疾病密切相關(guān)。本產(chǎn)品采用雜交瘤技術(shù)制備，具有高親和力與優(yōu)異特異性，可精準(zhǔn)識別人類、小鼠及大鼠樣本中TUBB1蛋白，適用于ELISA檢測和Western Blot免疫印跡實驗，滿足不同實驗體系需求。經(jīng)嚴(yán)格驗證的抗體性能可有效支持血小板生成機制研究、巨核細(xì)胞分化過程分析以及血小板相關(guān)疾病的分子機制探索，為血液系統(tǒng)疾病研究、心血管病理模型構(gòu)建及藥物作用靶點篩選等科研領(lǐng)域提供可靠工具。該TUBB1抗體特別適用于體外培養(yǎng)細(xì)胞模型、組織裂解液等樣本的蛋白水平檢測，兼容常規(guī)SDS-PAGE及轉(zhuǎn)膜實驗條件，是研究細(xì)胞骨架動態(tài)調(diào)控與血小板功能關(guān)聯(lián)性的理想選擇。
Uniprot No.：

Q9H4B7
基因名：

TUBB1
別名：

2810484G07Rik antibody; beta 1 tubulin antibody; Beta tubulin 1, class VI antibody; Beta-tubulin antibody; Class VI beta tubulin antibody; dJ543J19.4 antibody; M(beta)1 antibody; TBB1_HUMAN antibody; TUBB1 antibody; Tubulin beta 1 class VI antibody; Tubulin beta-1 chain antibody; Tubulin, beta 1 antibody; tubulin, beta1 antibody
宿主：

Mouse
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Synthetic Peptide
免疫原種屬：

H, R, M
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
克隆號：

29E1
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
基因功能參考文獻(xiàn)：
1. Neonatal platelets exhibit low levels of the Stx11-Munc18b complex (essential component of the SNARE machinery) and of beta1-tubulin. These developmental deficiencies are associated with defects in platelet adhesion, spreading and secretion. PMID: 29044293
2. novel DCX mutation (p.D90G, NP_000546.2) appeared to be a major causative variant, whereas the novel mutation of TUBB1 (p.R62fsX, NP_110400.1) was found only in patients with more-severe intellectual disability in Familial pachygyria PMID: 26743950
3. Analysis of the TUBB1 gene revealed three known missense variants in heterozygous state which in combination might explain the beta1-tubulin defect. PMID: 26540125
4. TUBB1 R307H SNP is significantly associated with the degree of thrombocytopenia in congenital and acquired platelet disorders, and may affect platelets by altering microtubule behavior. PMID: 25529050
5. Data indicate that ABCB1 protein, beta tubulin I and III (betaI, and betaIII tubulin) might contribute to the multidrug resistance (MDR) of MCF7/DOC and be potential therapeutic targets for overcoming MDR of breast cancer. PMID: 24894670
6. TUBB1 mutation disrupting microtubule assembly impairs proplatelet formation and results in congenital macrothrombocytopenia. PMID: 24344610
7. our findings define beta-tubulin VI as a hematologic isotype with significant genetic variation in humans that may affect the myelosuppresive action of microtubule-binding drugs PMID: 22805305
8. homozygous status of P43 genetic polymorphism causes alterations in platelet ultrastructure PMID: 21384078
9. Studies show that BFBTS bound and modified beta-tubulin at residue Cys12, forming beta-tubulin-SS-fluorobenzyl. PMID: 19996274
10. SLPI localizes in part along the megakaaryocyte and platelet cytoskeleton by virtue of specific interactions with beta1 tubulin. PMID: 15315966
11. the platelet Q43P beta1-tubulin substitution is frequent in the healthy population and may protect men against arterial thrombosis PMID: 15956286
12. The TUBB1 Q43P polymorphism, by causing a lower reactivity in platelets carrying the variant form of b1-tubulin, protects against thrombotic disorders but increases the risk of intracerebral hemorrhage in men. PMID: 17488662
13. biophysical analysis of carboxy-terminal tail conformation of human beta-tubulin isotypes PMID: 17993481
14. Mutation of the beta1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly. PMID: 18849486
15. TUBB1 Q43P polymorphism does not protect against acute coronary syndrome and premature myocardial infarction. PMID: 19132255
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相關(guān)疾病：

Macrothrombocytopenia, autosomal dominant, TUBB1-related (MAD-TUBB1)
亞細(xì)胞定位：

Cytoplasm, cytoskeleton.
蛋白家族：

Tubulin family
組織特異性：

Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins.
數(shù)據(jù)庫鏈接：

HGNC: 16257

OMIM: 612901

KEGG: hsa:81027

STRING: 9606.ENSP00000217133

UniGene: Hs.303023

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