Rat Interleukin 1α,IL-1α ELISA kit

Rat Interleukin 1α,IL-1α ELISA kit

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文獻引用 (6) 說明書下載

中文名稱：

大鼠白介素1α(IL-1α)酶聯(lián)免疫試劑盒
貨號：

CSB-E04622r
規(guī)格：

96T/48T
價格：

￥3200/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star? Award in the ELISA category

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產(chǎn)品描述：

大鼠白介素1α(IL-1α)酶聯(lián)免疫試劑盒（CSB-E04622r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿.樣本中的IL1A含量。IL1A 是一種細(xì)胞因子，在炎癥和免疫反應(yīng)中扮演關(guān)鍵角色。其背景上，它與多種疾病如自身免疫病、炎癥性疾病相關(guān)。研究機制顯示，IL1A 可激活下游信號通路，引發(fā)機體免疫細(xì)胞反應(yīng)和炎癥因子釋放，是潛在的疾病治療靶點。試劑盒檢測范圍為78 pg/ml-5000 pg/ml.，靈敏度為19.5 pg/ml.。適用于科研領(lǐng)域中對炎癥機制、免疫調(diào)控模型及藥物干預(yù)效果的評估，尤其適合同時分析體液樣本（血清/血漿）與組織局部IL - 1α表達水平。為研究IL - 1α在先天免疫應(yīng)答、細(xì)胞應(yīng)激反應(yīng)及病理狀態(tài)下的動態(tài)變化提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
別名：

IL1A ELISA Kit; Interleukin-1 alpha ELISA Kit; IL-1 alpha ELISA Kit
縮寫：

IL1A
Uniprot No.：

P04822
種屬：

Rattus norvegicus (Rat)
樣本類型：

serum, plasma, tissue homogenates.
檢測范圍：

78 pg/ml-5000 pg/ml.
靈敏度：

19.5 pg/ml.
反應(yīng)時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領(lǐng)域：

Immunology
測定原理：

quantitative
測定方法：

Sandwich

精密度：

線性度：

To assess the linearity of the assay, samples were spiked with high concentrations of rat IL-1α in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

	Sample	Serum(n=4)
1:1	Average %	96
	Range %	92-102
1:2	Average %	98
	Range %	91-104
1:4	Average %	101
	Range %	98-107
1:8	Average %	89
	Range %	84-96

回收率：

標(biāo)準(zhǔn)曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

pg/ml

OD1

OD2

Average

Corrected

5000

2.657

2.556

2.607

2.425

2500

2.123

2.022

2.073

1.891

1250

1.468

1.447

1.458

1.276

625

0.927

0.916

0.922

0.740

312

0.568

0.579

0.574

0.392

156

0.415

0.404

0.410

0.228

0.312

0.300

0.306

0.124

0.180

0.183

0.182

數(shù)據(jù)處理：

ELISA操作視頻及標(biāo)曲繪制軟件下載
貨期：

3-5 working days

Appraisal of the Pre-Emptive Effect of Lactoferrin Against Chromium-Induced Testicular Toxicity in Male Rats SS Abd El-Rahman,Biological trace element research,2023
Hepatoprotective Potential of Genkwanin Against Aflatoxin B1-Induced Biochemical, Inflammatory and Histopathological Toxicity in Rats MU Ijaz,Pakistan Veterinary Journal,2022
Electroacupuncture Prevents Osteoarthritis of High-Fat Diet-Induced Obese Rats X Lin-Lin,BIOMED RESEARCH INTERNATIONAL,2020
Volatile Oil of Amomum villosum Inhibits Nonalcoholic Fatty Liver Disease via the Gut-Liver Axis Shanhong Lu.et al,BioMed Research International,2018
Magnesium isoglycyrrhizinate inhibits inflammatory response through STAT3 pathway to protect remnant liver function Tang GH. et al,World J Gastroenterol,2015
Ethyl-p-methoxycinnamate isolated from kaempferia galanga inhibits inflammation by suppressing interleukin-1, tumor necrosis factor-a, and angiogenesis by blocking endothelial functions. Umar MI et al,Clinics,2014

功能：

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
基因功能參考文獻：
1. We propose that induction of collagenase-1 by IL-1alpha in both WF and NF depends on a unique combination of cell type-specific signaling pathways. PMID: 17455222
亞細(xì)胞定位：

Cytoplasm. Secreted.
蛋白家族：

IL-1 family
數(shù)據(jù)庫鏈接：

KEGG: ocu:100009250

STRING: 9986.ENSOCUP00000007573

UniGene: Ocu.2080

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.