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中文名稱：人8羥基脫氧鳥苷(8-OHdG)酶聯免疫試劑盒
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貨號：CSB-E10140h
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規格：96T/48T
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價格：￥3600/￥2500
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其他：
產品詳情
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產品描述：人8羥基脫氧鳥苷(8-OHdG)酶聯免疫試劑盒（CSB-E10140h）為競爭法ELISA試劑盒，定量檢測血清、尿液樣本中的8-OHdG含量。8-OHdG是細胞內DNA氧化應激損傷的標志性產物。其背景在于機體受內外部因素影響產生氧化應激，損傷DNA生成8-OHdG。研究機制方面，常檢測其水平以評估氧化應激程度，在疾病早期診斷、病情監測及藥物研發等領域有重要意義。試劑盒檢測范圍為 3.12 ng/mL-800 ng/mL，該產品適用于體外定量評估生物樣本中的氧化損傷水平，為探索氧化應激與疾病關聯機制、藥物篩選及毒理學研究提供高效工具，尤其適合需要高靈敏度和寬線性范圍的科研場景，滿足血清和尿液等易獲取樣本的便捷檢測需求。在衰老、腫瘤發生、神經退行性疾病及環境毒理等研究領域具有重要科研價值。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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縮寫：8-OHdG
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種屬：Homo sapiens (Human)
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樣本類型：serum, urine
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檢測范圍：3.12 ng/mL-800 ng/mL
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靈敏度：3.12 ng/mL
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Cell Biology
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測定原理：quantitative
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測定方法：Competitive
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精密度：
Intra-assay Precision (Precision within an assay): CV%<12%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<15%
Three samples of known concentration were tested in twenty assays to assess.
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線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of human 8-OHdG in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
Sample
Serum(n=4)
1:1
Average %
84
Range %
80-91
1:2
Average %
87
Range %
81-95
1:4
Average %
88
Range %
82-95
1:8
Average %
86
Range %
81-92
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回收率：
The recovery of human 8-OHdG spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
Sample Type
Average % Recovery
Range
Serum (n=5)
89
84-96
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標準曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
ng/ml
OD1
OD2
Average
Corrected
800
0.337
0.344
0.340
0.340
200
0.873
0.857
0.865
0.865
50
1.302
1.328
1.315
1.315
12.5
1.784
1.699
1.741
1.741
3.12
2.190
2.291
2.240
2.240
0
2.534
2.453
2.493
2.493
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數據處理：
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貨期：3-5 working days
引用文獻
- Epigenetic modifications of nuclear and mitochondrial DNA are associated with the disturbance of serum iron biomarkers among the metabolically unhealthy obesity school-age children L Xia, X Luo, Y Liang, X Jiang, W Yang, J Yan, K Qi,Nutrition Journal,2025
- Poria cocos-Derived Exosome-like Nanovesicles Alleviate Metabolic Dysfunction-Associated Fatty Liver Disease by Promoting Mitophagy and Inhibiting NLRP3 Inflammasome Activation T Wang, J Zhao, QY Li, HQ Yang, M Li, R Duan,International Journal of Molecular Sciences,2025
- Chlamydia psittaci Infection Induces IFN-I and IL-1β Through the cGAS-STING-IRF3/NLRP3 Pathway via Mitochondrial Oxidative Stress in Human Macrophages H Yang, P Sun, S Zhou, Y Tang, S Li, W Li, X Yu,Veterinary Microbiology,2024
- Therapeutic Framework Nucleic Acid Complexes Targeting Oxidative Stress and Pyroptosis for the Treatment of Osteoarthritis J Li, Y Li, X Shang, S Xu, Z Zhang, S Xu, X Wang,Materials Today Bio,2024
- Date seed (phoenix dactylifera) supplementation modulates oxidative DNA damage, lipid peroxidation, and cardiometabolic risk factors in type 2 diabetes: A triple-blinded randomized placebo-controlled trial E Karimi,Journal of Functional Foods,2024
- PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis W Lai,Communications biology,2024
- Serum 8-Hydroxy-2'-deoxyguanosine Predicts Severity and Prognosis of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Cao Peng,Lung,2023
- Serum 8-Hydroxy-2′-deoxyguanosine Predicts Severity and Prognosis of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease P Cao,Lung,2023
- Subclinical cardiovascular outcomes of acute exposure to fine particulate matter and its constituents: A glutathione S-transferase polymorphism-based longitudinal study J Song,The Science of the total environment,2023
- Biological Markers in Newly Diagnosed Generalized Anxiety Disorder Patients: 8-OHdG S100B and Oxidative Stress F Zhou,Neuropsychiatric disease and treatment,2024
- The effects of ketogenic diet on beta-hydroxybutyrate, arachidonic acid, and oxidative stress in pediatric epilepsy B Poorshiri,Epilepsy & behavior,2023
- Aspartame Consumption, Mitochondrial Disorder-Induced Impaired Ovarian Function, and Infertility Risk YC Chen,International journal of molecular sciences,2022
- Protective effect of green synthesized Selenium Nanoparticles against Doxorubicin induced multiple adverse effects in Swiss albino mice MA Khan,Life sciences,2022
- Sitagliptin protects renal glomerular endothelial cells against high glucose-induced dysfunction and injury L Xu,Bioengineered,2022
- Serum 8-Hydroxydeoxyguanosine Is a Potential Indicator for the Severity and Prognosis in Patients with Community-Acquired Pneumonia: A Prospective Cohort Study LF Cao,Journal of immunology,2021
- Interleukin-17 and oxidative stress in children with immunoglobulin A vasculitis H Kisaoglu,Scandinavian Journal of Rheumatology,2021
- Biomarkers of nucleic acid oxidation–a summary state-of-the-art MR Chao,Redox Biology,2021
- Respiratory effects induced by occupational exposure to refractory ceramic fibers Y Gu,Journal of Applied Toxicology,2020
- The profile of urinary biomarkers in overactive bladder MP Rada,Neurourology and Urodynamics,2020
- OXIDATIVE STRESS, DNA DAMAGE AND APOPTOSIS LEVELS IN THOSE WHO USE BORDERLINE HIGH LEVEL FLUORIDE CONTENT DRINKING WATER A Kirmit,Journal of Contemporary Medicine,2020
- Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose?response manner in subjects with dyslipidemia H Zhang,Redox Biology,2020
- Short time exposure to ambient ozone and associated cardiovascular effects: A panel study of healthy young adults Song J,Environ Int,2020
- Bioavailability and Cytotoxicity of Cerium-(IV), Copper-(II), and Zinc Oxide Nanoparticles to human intestinal and liver cells through food Li J, et al,Science of The Total Environment,2019
- Urinary NGAL and RBP Are Biomarkers of Normoalbuminuric Renal Insufficiency in Type 2 Diabetes Mellitus Li A, et al,Journal of Immunology Research,2019
- Anthocyanins from black peanut skin protect UV-B induced keratinocyte cells and skin oxidative damage through activating Nrf 2 signaling Kai Kai Li, et al,Food & Function,2019
- Evaluation of Serum 8-Hydroxy-Deoxyguanosine, Interleukin-6 and Interleukin-7 in Type 2 Diabetic Iraqi Females Alaaraji SFT, et al,Journal of global pharma technology,2019
- FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX Linlin Ji, et al,Oxidative medicine and cellular longevity,2019
- Research Paper Effects of an 8-Week Aerobic Exercise Program on Some Indicators of Oxidative Stress in Elderly Women K Hejazi, et al,Iranian Journal Of Ageing,2019
- Serum 8-Hydroxy-2-Deoxyguanosine Level as a Potential Biomarker of Oxidative DNA Damage Induced by Ionizing Radiation in Human Peripheral Blood Yu Gao, et al,Dose-Response,2019
- Changes of 8-OHdG and TrxR in the Residents Who Bathe in Radon Hot Springs Gao Yanxiao, et al,Dose-Response,2019
- Photo-Oxidative Blue-Light Stimulation in Retinal Pigment Epithelium Cells Promotes Exosome Secretion and Increases the Activity of the NLRP3 Inflammasome Wei Zhang.et al,Current Eye Research,2018
- Evidence for Adaptive Response in a Molecular Epidemiological Study of the Inhabitants of a High Background-radiation Area of Yangjiang, China Su, Shibiao.et al,Health Physics,2018
- Salvianolic Acid A Protects Against Diabetic Nephropathy through Ameliorating Glomerular Endothelial Dysfunction via Inhibiting AGE-RAGE Signaling Hou B.et al,Cell Physiol Biochem,2017
- Flavone protects HBE cells from DNA double-strand breaks caused by PM2. 5 Ren X.et al,Hum Cell,2017
- Hesperidin Supplementation Alleviates Oxidative DNA Damage and Lipid Peroxidation in Type 2 Diabetes: A Randomized Double-Blind Placebo-Controlled Clinical Trial Homayouni F.et al,Phytother Res.,2017
- Oxidative DNA damage in the pathogenesis of chronic obstructive pulmonary disease in older patients O. Yu. Kytikova.et al,Adv Gerontol,2017
- Role of oxidative stress and DNA hydroxymethylation in the neurotoxicity of fine particulate matter Wei H.et al,Toxicology. ,2017
- Molecular mechanisms of dust-induced toxicity in human corneal epithelial cells: Water and organic extract of office and house dust. Xiang P.et al,Environ Int.,2016
- Tumor Necrosis Factor-Alpha and 8-Hydroxy-2'-Deoxyguanosine are Associated with Elevated Urinary Angiopoietin-2 Level in Type 2 Diabetic Patients with Albuminuria. He FF.et al,Kidney Blood Press Res.,2015
- β-glucans: ex vivo inflammatory and oxidative stress results after pasta intake. Barera A.et al,Immun Ageing.,2016
- Genotoxic risk of quinocetone and its possible mechanism in in vitro studies Wang X.et al,Toxicology Research,2016
- Mechanisms of housedust-induced toxicity in primary human corneal epithelial cells: Oxidative stress, proinflammatory response and mitochondrial dysfunction. Xiang P. et al,Environ Int.,2016
- Evaluation of Oxidative DNA Damage and Its Relation with Anthropometric Indices in Healthy Adolescents Farzaneh Bagherzadeh1 et al,International Journal of Nutrition and Food Sciences,2015
- PRDX6 Protects ARPE-19 Cells from Oxidative Damage via PI3K/AKT Signaling X Zha. et al,Cell Physiol Biochem,2015
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靶點詳情
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最新研究進展：8-OHdG是DNA氧化損傷的標志物，最新研究表明，其與各種疾病的發生和發展有關，包括癌癥、糖尿病、阿爾茨海默病等。此外，8-OHdG的水平也可以用作生活方式和環境暴露的生物標志物。
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