WWTR1
WW domain-containing transcription regulator protein 1 is a protein in humans that is encoded by WWTR1 gene. Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
WWTR1 Antibodies
WWTR1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA563551 | WWTR1 Antibody | Human,Mouse,Rat | ELISA,WB |
WWTR1 Proteins
WWTR1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP887643MO CSB-EP887643MO CSB-BP887643MO CSB-MP887643MO CSB-EP887643MO-B |
Recombinant Mouse WW domain-containing transcription regulator protein 1 (Wwtr1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
WWTR1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP887938HU CSB-EP887938HU CSB-BP887938HU CSB-MP887938HU CSB-EP887938HU-B |
Recombinant Human WW domain-containing transcription regulator protein 1 (WWTR1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
