USP33
USP33，即泛素特異性蛋白酶33，別名Ubiquitin-specificproteases33。它是由人類基因組中的USP33基因編碼的蛋白酶，屬于去泛素化酶家族的重要成員。USP33在細(xì)胞內(nèi)主要通過對(duì)底物蛋白的去泛素化來阻止蛋白酶體降解，進(jìn)而調(diào)節(jié)細(xì)胞內(nèi)多種生命活動(dòng)，包括信號(hào)通路、自噬、中心體擴(kuò)增以及腫瘤發(fā)生發(fā)展。其作用機(jī)制涉及與特定蛋白質(zhì)相互作用，通過去除泛素鏈來調(diào)節(jié)這些蛋白質(zhì)的穩(wěn)定性和活性，如通過deubiquitinationofthecentriolarproteinCP110調(diào)節(jié)中心體生物合成。USP33在維持細(xì)胞內(nèi)蛋白穩(wěn)態(tài)、細(xì)胞周期調(diào)控、基因組穩(wěn)定性以及腫瘤發(fā)生中發(fā)揮重要作用。USP33的異常表達(dá)與多種疾病相關(guān)，尤其是在腫瘤的預(yù)防、治療及預(yù)后中可能提供新的治療方向。
熱銷產(chǎn)品
USP33 Antibody (CSB-PA840583LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Hela whole cell lysate
All lanes: USP33 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 107, 104, 94 kDa
Observed band size: 107 kDa
Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA840583LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA840583LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
USP33 Antibodies
USP33 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA025724GA01HU | USP33 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA840583LA01HU | USP33 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA840583LB01HU | USP33 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA840583LC01HU | USP33 Antibody, FITC conjugated | Human |
USP33 Proteins
USP33 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP840583HU CSB-EP840583HU CSB-BP840583HU CSB-MP840583HU CSB-EP840583HU-B |
Recombinant Human Ubiquitin carboxyl-terminal hydrolase 33 (USP33), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
