UBA6
UBA6（Ubiquitin-like modifier-activating enzyme 6）是人體中由UBA6基因編碼的一種蛋白質(zhì)。UBA6蛋白通過將ATP與其C端的甘氨酸殘基腺苷化，然后將這個(gè)殘基連接到E1中半胱氨酸的側(cè)鏈上，形成一個(gè)泛素-E1巰基酯和游離的AMP（腺苷二磷酸）。UBA6專一于泛素，不激活類似泛素的肽鏈。與UBE1在底物E2充電特異性上有所不同，不會(huì)充電細(xì)胞周期E2，如CDC34。UBA6對胚胎發(fā)育至關(guān)重要。它還參與UBD/FAT10的結(jié)合過程。UBA6的第二剪切異構(gòu)體可能在泛素系統(tǒng)中起關(guān)鍵作用，影響精子發(fā)生和男性生育能力。
UBA6抗體是用于檢測和研究UBA6蛋白表達(dá)和功能的抗體。UBA6蛋白參與多個(gè)通路，包括泛素化，特別是UBD/FAT10的結(jié)合過程。
UBA6蛋白是一種泛素樣修飾系統(tǒng)中的活化酶，具有將泛素與目標(biāo)蛋白連接的功能。它通過將泛素激活，形成泛素-UBA6的腺苷酸共價(jià)結(jié)合物，然后將其轉(zhuǎn)移給泛素連接酶（E2）來進(jìn)行進(jìn)一步的修飾。
UBA6在細(xì)胞內(nèi)起著重要的調(diào)節(jié)作用。它參與調(diào)控蛋白質(zhì)降解、細(xì)胞周期調(diào)控、DNA修復(fù)、信號(hào)傳導(dǎo)、免疫應(yīng)答等生物學(xué)過程。UBA6還與腫瘤發(fā)生和發(fā)展、神經(jīng)退行性疾病等疾病相關(guān)。
通過研究UBA6抗體和UBA6蛋白參與的通路，可以深入了解其在細(xì)胞功能和疾病機(jī)制中的作用，為疾病診斷和治療提供理論依據(jù)和新的治療靶點(diǎn)。
Ubiquitin-like modifier-activating enzyme 6 is a protein in humans that is encoded by UBA6 gene. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.
UBA6 Antibodies
UBA6 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA025420GA01HU | UBA6 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA025420ESR1HU | UBA6 Antibody | Human | ELISA, IHC |
| CSB-PA025420ESR2HU | UBA6 Antibody | Human | ELISA, IHC |
| CSB-PA025420LA01HU | UBA6 Antibody | Human | ELISA, IHC, IF |
| CSB-PA025420LB01HU | UBA6 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA025420LC01HU | UBA6 Antibody, FITC conjugated | Human |
UBA6 Proteins
UBA6 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025420HU CSB-EP025420HU CSB-MP025420HU CSB-EP025420HU-B |
Recombinant Human Ubiquitin-like modifier-activating enzyme 6 (UBA6), partial | Yeast E.coli Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-BP025420HUe0 | Recombinant Human Ubiquitin-like modifier-activating enzyme 6(UBA6), partial | Baculovirus |
| CSB-BP025420HU | Recombinant Human Ubiquitin-like modifier-activating enzyme 6 (UBA6), partial | Baculovirus |
UBA6 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP804468MO CSB-EP804468MO CSB-BP804468MO CSB-MP804468MO CSB-EP804468MO-B |
Recombinant Mouse Ubiquitin-like modifier-activating enzyme 6 (Uba6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
