TNFSF10

TNFSF10（腫瘤壞死因子超家族成員10）又稱TRAIL（腫瘤壞死因子相關凋亡誘導配體），是一種Ⅱ型跨膜蛋白，其可溶性形式通過激活死亡受體DR4和DR5觸發細胞凋亡。TNFSF10在免疫監視中起關鍵作用，可選擇性誘導癌細胞凋亡而不損傷正常組織，這一特性使其成為腫瘤治療的熱點靶點。其作用涉及線粒體途徑和Caspase蛋白酶級聯反應，同時受凋亡抑制蛋白c-FLIP和Bcl-2家族調控。
TRAIL在肝癌、肺癌等多種惡性腫瘤中表達異常，其信號通路失調與腫瘤耐藥密切相關。近年來，針對TRAIL受體的單克隆抗體如Conatumumab、Lexatumumab已進入臨床試驗，但單藥療效有限，現多探索與化療或靶向藥的聯合應用。另有研究揭示TRAIL在阿爾茨海默病中可能通過清除異常蛋白沉積發揮保護作用，但過度激活也可能導致神經元損傷。目前新型融合蛋白如TRAIL-Fc和三特異性抗體正在開發中，旨在提高受體結合特異性和克服耐藥性瓶頸。

熱銷產品

Recombinant Human Tumor necrosis factor ligand superfamily member 10 (TNFSF10), partial (CSB-EP023985HU)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TNFSF10 Antibody (CSB-PA07475A0Rb)

驗證數據

Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA07475A0Rb at dilution of 1:100

Immunofluorescence staining of A549 cells with CSB-PA07475A0Rb at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

TNFSF10 Antibody

TNFSF10 Protein

TNFSF10 ELISA Kit

TNFSF10 Antibodies

TNFSF10 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA07475A0Rb	TNFSF10 Antibody	Human	ELISA, IHC, IF
CSB-PA023985GA01HU	TNFSF10 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA272904	TNFSF10 Antibody	Human	ELISA,WB,IF
CSB-PA004326	TNFSF10 Antibody	Human	WB, IHC, IF, ELISA
CSB-PA005996	TNFSF10 Antibody	Human	WB, ELISA

TNFSF10 Proteins

TNFSF10 Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP023985MO CSB-EP023985MO CSB-BP023985MO CSB-MP023985MO CSB-EP023985MO-B	Recombinant Mouse Tumor necrosis factor ligand superfamily member 10 (Tnfsf10)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TNFSF10 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP023985HU CSB-BP023985HU CSB-MP023985HU CSB-EP023985HU-B	Recombinant Human Tumor necrosis factor ligand superfamily member 10 (TNFSF10), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP023985HUe0	Recombinant Human Tumor necrosis factor ligand superfamily member 10 (TNFSF10), partial	E.coli
CSB-EP023985HU	Recombinant Human Tumor necrosis factor ligand superfamily member 10 (TNFSF10), partial	E.coli
CSB-CF023985HU	Recombinant Human Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	in vitro E.coli expression system
CSB-AP004901HU	Recombinant Human Tumor necrosis factor ligand superfamily member 10 (TNFSF10), partial (Active)	E.coli

TNFSF10 ELISA Kit

TNFSF10 ELISA Kit for Homo sapiens (Human)

產品貨號	產品名稱	樣本類型	靈敏度
CSB-E04750h	Human soluble tumor necrosis factor-related apoptosis inducing ligand,sTRAIL ELISA KIT	serum, plasma, tissue homogenates	3.9 pg/ml
CSB-E04750h-IS	Human soluble tumor necrosis factor-related apoptosis inducing ligand,sTRAIL ELISA KIT	serum, plasma, cell culture supernates, tissue homogenates	1.95 pg/mL