TMEM132B
TMEM132B，即跨膜蛋白132B。別名RGD1566191。它在人體中廣泛表達(dá)，尤其在大腦中。TMEM132B的作用機(jī)制涉及與GABAA受體的相互作用，增強(qiáng)酒精對(duì)GABAA受體的正向變構(gòu)效應(yīng)，并調(diào)節(jié)GABAA受體離子通道的動(dòng)力學(xué)。TMEM132B對(duì)調(diào)節(jié)酒精行為效應(yīng)具有重要作用，基因敲除TMEM132B的小鼠表現(xiàn)出飲酒量增加，并降低酒精的鎮(zhèn)定與催眠效應(yīng)。這一發(fā)現(xiàn)為理解酒精如何在大腦中調(diào)節(jié)行為提供了新的分子視角，并為臨床治療酒精成癮以及新藥研發(fā)提供了可能的理論指導(dǎo)。
熱銷產(chǎn)品
Recombinant Human Transmembrane protein 132B (TMEM132B), partial
CSB-YP023700HU
來(lái)源：Yeast
CSB-EP023700HU
來(lái)源：E.coli
CSB-BP023700HU
來(lái)源：Baculovirus
CSB-MP023700HU
來(lái)源：Mammalian cell
CSB-EP023700HU-B
來(lái)源：In Vivo Biotinylation in E.coli
TMEM132B Proteins
TMEM132B Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP023700HU CSB-EP023700HU CSB-BP023700HU CSB-MP023700HU CSB-EP023700HU-B |
Recombinant Human Transmembrane protein 132B (TMEM132B), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
