TIGAR
TIGAR，即TP53誘導(dǎo)的糖酵解和凋亡調(diào)節(jié)劑，別名FR2BP、C12orf5。它是一種在細(xì)胞對(duì)p53相關(guān)應(yīng)激反應(yīng)中起重要作用的蛋白，由人體細(xì)胞自身的基因編碼。TIGAR的作用機(jī)制主要是通過(guò)抑制糖酵解途徑，增加磷酸戊糖途徑的流量，從而產(chǎn)生更多的NADPH，以促進(jìn)DNA修復(fù)和減少細(xì)胞內(nèi)活性氧(ROS)的產(chǎn)生，保護(hù)細(xì)胞免受氧化應(yīng)激引起的損傷。TIGAR在生物學(xué)上的意義非常廣泛，它參與調(diào)節(jié)細(xì)胞的代謝、氧化還原平衡、細(xì)胞周期、細(xì)胞凋亡以及自噬等過(guò)程。TIGAR的表達(dá)與多種疾病的發(fā)生發(fā)展密切相關(guān)，尤其是在腫瘤發(fā)展中，TIGAR通過(guò)抗氧化作用和調(diào)節(jié)自噬，有助于腫瘤細(xì)胞逃避免疫監(jiān)視和增強(qiáng)腫瘤細(xì)胞的侵襲能力。此外，TIGAR的功能異常還與某些心血管疾病和神經(jīng)退行性疾病相關(guān)。因此，TIGAR是藥物開(kāi)發(fā)和疾病治療中的一個(gè)潛在靶點(diǎn)。
熱銷(xiāo)產(chǎn)品
Recombinant Human Fructose-2,6-bisphosphatase TIGAR protein (TIGAR) (CSB-AP000111HU)
驗(yàn)證數(shù)據(jù)
TIGAR Antibody (CSB-PA889078LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA889078LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA889078LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA889078LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
TIGAR Antibodies
TIGAR for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA202764 | TIGAR Antibody | Human | ELISA,IHC |
| CSB-PA162542 | TIGAR Antibody | Human | ELISA,WB,IHC |
| CSB-PA889078LA01HU | TIGAR Antibody | Human | ELISA, IHC, IF |
| CSB-PA889078LC01HU | TIGAR Antibody, FITC conjugated | Human | |
| CSB-PA889078LD01HU | TIGAR Antibody, Biotin conjugated | Human | ELISA |
TIGAR Proteins
TIGAR Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP889078HU CSB-EP889078HU CSB-BP889078HU CSB-MP889078HU CSB-EP889078HU-B |
Recombinant Human Probable fructose-2,6-bisphosphatase TIGAR (TIGAR) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP000111HU | Recombinant Human Fructose-2,6-bisphosphatase TIGAR protein (TIGAR) | E.Coli |
