TIE1
TIE1，全稱為酪氨酸蛋白激酶受體Tie1，是一種跨膜蛋白，在血管生成和穩(wěn)態(tài)中發(fā)揮關(guān)鍵作用。它屬于免疫球蛋白樣和表皮生長(zhǎng)因子同源受體酪氨酸激酶家族，常見(jiàn)別名為T(mén)EK。TIE1蛋白通過(guò)與TIE2蛋白形成異源二聚體，調(diào)節(jié)血管內(nèi)皮細(xì)胞的活化和穩(wěn)定性，對(duì)血管的發(fā)育和維持至關(guān)重要。研究發(fā)現(xiàn)，TIE1蛋白在多種生理和病理過(guò)程中發(fā)揮作用，包括胚胎發(fā)育、傷口愈合和腫瘤血管生成。TIE1蛋白的異常表達(dá)或功能失調(diào)與多種疾病相關(guān)，如肝纖維化、膿毒癥和腫瘤。在藥物研發(fā)方面，針對(duì)TIE1蛋白的靶向藥物正在開(kāi)發(fā)中，旨在治療血管相關(guān)疾病和腫瘤。例如，一些研究將TIE1蛋白作為抗血管生成治療的潛在靶點(diǎn)，以抑制腫瘤血管生成和轉(zhuǎn)移。此外，TIE1蛋白也被用作診斷和預(yù)后標(biāo)志物，如肝纖維化的潛在診斷標(biāo)志物。總之，TIE1蛋白在血管生物學(xué)和疾病治療中具有重要意義，未來(lái)有望為相關(guān)疾病的治療提供新的策略。
熱銷(xiāo)產(chǎn)品
TIE1 Antibody (CSB-PA07369A0Rb)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA07369A0Rb at dilution of 1:100
Immunofluorescent analysis of A549 cells using CSB-PA07369A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human tyrosine kinase with immunoglobulin-like and EGF-like domains 1,Tie-1 ELISA kit (CSB-E04728h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E04728h
規(guī)格：96T/48T
靈敏度：0.23 ng/mL
檢測(cè)范圍：0.94 ng/mL-60 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
TIE1 Antibodies
TIE1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA023534GA01HU | TIE1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA201956 | TIE1 Antibody | Human | ELISA,WB |
| CSB-PA050264 | TIE1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA07369A0Rb | TIE1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA07369B0Rb | TIE1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA07369C0Rb | TIE1 Antibody, FITC conjugated | Human | |
| CSB-PA07369D0Rb | TIE1 Antibody, Biotin conjugated | Human | ELISA |
TIE1 Proteins
TIE1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP023534HU CSB-EP023534HU CSB-BP023534HU CSB-MP023534HU CSB-EP023534HU-B |
Recombinant Human Tyrosine-protein kinase receptor Tie-1 (TIE1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TIE1 ELISA Kit
TIE1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-E04728h | Human tyrosine kinase with immunoglobulin-like and EGF-like domains 1,Tie-1 ELISA kit | serum, plasma, tissue homogenates | 0.23 ng/mL |
