THPO

THPO，全稱促血小板生成素，是一種由人體內(nèi)THPO基因編碼的糖蛋白激素，也被稱為巨核細(xì)胞生長衍生因子（MGDF）。它主要由腎臟和肝臟分泌，能夠刺激巨核細(xì)胞的形成和分化，進(jìn)而促進(jìn)血小板的生成。THPO通過與MPL受體結(jié)合，激活下游信號通路，促進(jìn)巨核細(xì)胞增殖、分化和成熟，最終形成血小板。在臨床上，THPO主要用于治療血小板減少癥，如原發(fā)免疫性血小板減少癥（ITP）和化療后血小板恢復(fù)，以及預(yù)防腫瘤治療引起的血小板減少。目前，全球已有多種THPO類似物和受體激動劑獲批上市，如重組人血小板生成素（rhTPO）、羅普司亭、艾曲泊帕等，這些藥物通過不同方式激活THPO受體，提高血小板計(jì)數(shù)，改善患者的出血風(fēng)險(xiǎn)。此外，THPO在肝病和移植領(lǐng)域也有應(yīng)用，如肝衰竭時(shí)TPO水平下降可作為預(yù)后標(biāo)志物，而在干細(xì)胞移植中，TPO預(yù)處理可增強(qiáng)造血干細(xì)胞歸巢效率。目前，科學(xué)家們還在研究THPO在腫瘤治療副作用、骨髓纖維化等疾病中的應(yīng)用，以及開發(fā)新型THPO類似物和受體激動劑，以進(jìn)一步提高療效和安全性。

熱銷產(chǎn)品

Recombinant Human Thrombopoietin (THPO) (Active) (CSB-MP023509HU(A4))

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of MO7e cells is 0.4353 - 1.089 ng/mL.

THPO Antibody (CSB-PA005677)

驗(yàn)證數(shù)據(jù)

Western Blot analysis of MCF-7 cells using TPO Polyclonal Antibody.

Human Thrombopoietin,TPO ELISA kit (CSB-E04745h)

驗(yàn)證數(shù)據(jù)

貨號：CSB-E04745h

規(guī)格：96T/48T

靈敏度：1.56 pg/mL

檢測范圍：6.25 pg/mL-400 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

THPO Antibody

THPO Protein

THPO ELISA Kit

THPO Antibodies

THPO for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA005677	THPO Antibody	Human	WB, ELISA

THPO for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA07649A0Rb	Thpo Antibody	Rat, Mouse, Human	ELISA, WB
CSB-PA07649B0Rb	Thpo Antibody, HRP conjugated	Rat	ELISA

THPO Proteins

THPO Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP023509HU CSB-BP023509HU CSB-MP023509HU CSB-EP023509HU-B	Recombinant Human Thrombopoietin (THPO)，partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP023509HU	Recombinant Human Thrombopoietin (THPO)，partial	E.coli
CSB-AP003971HU	Recombinant Human Thrombopoietin (THPO) (Active)	Mammalian cell
CSB-EP023509HUc7	Recombinant Human Thrombopoietin (THPO), partial	E.coli
CSB-MP023509HU(A4)	Recombinant Human Thrombopoietin (THPO) (Active)	Mammalian cell
CSB-BP023509HU(A4)	Recombinant Human Thrombopoietin (THPO)	Baculovirus

THPO Proteins for Sus scrofa (Pig)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP023509PI CSB-EP023509PI CSB-BP023509PI CSB-MP023509PI CSB-EP023509PI-B	Recombinant Pig Thrombopoietin (THPO), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

THPO Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP023509MO CSB-EP023509MO CSB-BP023509MO CSB-MP023509MO CSB-EP023509MO-B	Recombinant Mouse Thrombopoietin (Thpo)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP003451MO	Recombinant Mouse Thrombopoietin protein (Thpo), partial (Active)	E.Coli

THPO Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP023509DO CSB-EP023509DO CSB-BP023509DO CSB-MP023509DO CSB-EP023509DO-B	Recombinant Dog Thrombopoietin (THPO)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

THPO Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP023509RA CSB-EP023509RA CSB-BP023509RA CSB-MP023509RA CSB-EP023509RA-B	Recombinant Rat Thrombopoietin (Thpo)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-RP076444r	Recombinant Rat Thrombopoietin (Thpo), partial	E.coli