TBX5
TBX5，即胸腺素盒轉(zhuǎn)錄因子5，是一種轉(zhuǎn)錄因子，屬于T-box家族成員之一。TBX5在心臟發(fā)育、肺部形成和一些腫瘤的發(fā)生中起著重要作用。其作用機(jī)制涉及到與DNA上的特定位點(diǎn)結(jié)合，調(diào)控下游基因的表達(dá)。TBX5通過(guò)影響多種信號(hào)通路，包括但不限于PI3K-AKT、Wnt/β-catenin等，調(diào)控細(xì)胞的增殖、分化和遷移。在生物學(xué)意義上，TBX5對(duì)心臟和肺部的正常發(fā)育至關(guān)重要，其表達(dá)異常與某些先天性心臟病和肺疾病相關(guān)。此外，TBX5在肺癌等多種腫瘤中的作用也受到關(guān)注，其可能通過(guò)影響細(xì)胞周期和轉(zhuǎn)移相關(guān)基因的表達(dá)，促進(jìn)腫瘤的發(fā)展和轉(zhuǎn)移。
熱銷產(chǎn)品
Recombinant Human T-box transcription factor TBX5 (TBX5) (CSB-EP857866HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA995324(TBX5 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA995324(TBX5 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse kidney tissue, Primary antibody: CSB-PA995324(TBX5 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
TBX5 Antibodies
TBX5 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA023257GA01HU | TBX5 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA995324 | TBX5 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA869654 | TBX5 Antibody | Human,Mouse,Rat | ELISA,IHC |
TBX5 Proteins
TBX5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP857866HU CSB-BP857866HU CSB-MP857866HU CSB-EP857866HU-B |
Recombinant Human T-box transcription factor TBX5 (TBX5) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP857866HU | Recombinant Human T-box transcription factor TBX5 (TBX5) | E.coli |
