SUN2
SUN2 is a protein in humans that is encoded by SUN2 gene. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.
SUN2 Antibodies
SUN2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA883386LA01HU | SUN2 Antibody | Human, Mouse, Rat | ELISA, WB, IHC |
| CSB-PA883386LB01HU | SUN2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA883386LC01HU | SUN2 Antibody, FITC conjugated | Human | |
| CSB-PA883386LD01HU | SUN2 Antibody, Biotin conjugated | Human | ELISA |
SUN2 Proteins
SUN2 Proteins for Dictyostelium discoideum (Slime mold)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP703778DKK CSB-EP703778DKK CSB-BP703778DKK CSB-MP703778DKK CSB-EP703778DKK-B |
Recombinant Dictyostelium discoideum SUN domain-containing protein 2 (sun2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SUN2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP804816MO1 CSB-EP804816MO1 CSB-BP804816MO1 CSB-MP804816MO1 CSB-EP804816MO1-B |
Recombinant Mouse SUN domain-containing protein 2 (Sun2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF804816MO | Recombinant Mouse SUN domain-containing protein 2 (Sun2) | in vitro E.coli expression system |
SUN2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP883386HU1 CSB-EP883386HU1 CSB-BP883386HU1 CSB-MP883386HU1 CSB-EP883386HU1-B |
Recombinant Human SUN domain-containing protein 2 (SUN2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF883386HU | Recombinant Human SUN domain-containing protein 2 (SUN2) | in vitro E.coli expression system |
