STK40
STK40，即絲氨酸/蘇氨酸激酶40，別名SHIK、SgK495。STK40是一種假激酶，具有激酶同源結(jié)構(gòu)域但缺乏催化活性，主要通過作為支架蛋白協(xié)助E3泛素連接酶與底物蛋白結(jié)合，促進(jìn)蛋白的泛素化和降解。STK40可調(diào)控Th1和Th17細(xì)胞的分化，介導(dǎo)炎癥和自身免疫疾病進(jìn)展中的重要功能，通過促進(jìn)FOXO轉(zhuǎn)錄因子與E3連接酶COP1的相互作用，促進(jìn)K48連接的多泛素化和蛋白酶體降解。STK40在多種生理過程中發(fā)揮作用，包括細(xì)胞分化、免疫反應(yīng)調(diào)節(jié)以及可能的能量代謝調(diào)節(jié)，其異常表達(dá)與多種疾病相關(guān)，包括自身免疫性疾病和腫瘤。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA112765(STK40 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA112765(STK40 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue, Primary antibody: CSB-PA112765(STK40 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
STK40 Antibodies
STK40 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA112765 | STK40 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA158011 | STK40 Antibody | Human,Mouse,Rat | ELISA,IHC |
STK40 Proteins
STK40 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP854027HU CSB-EP854027HU CSB-BP854027HU CSB-MP854027HU CSB-EP854027HU-B |
Recombinant Human Serine/threonine-protein kinase 40 (STK40) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
