STK33
STK33,即絲氨酸/蘇氨酸激酶33,它是一種在人體多種組織中表達的蛋白激酶,屬于鈣/鈣調蛋白依賴性激酶家族成員。STK33在細胞中的表達受細胞密度控制,并且在頭頸腫瘤等手術切除標本中的表達量顯著高于正常或癌旁組織。其作用機制涉及自磷酸化功能,能夠對下游基因如Vimentin蛋白進行磷酸化修飾,影響其生物學功能。STK33還可能通過非激酶活性依賴途徑影響C-Myc基因的轉錄作用。在信號通路方面,STK33與ERK1/2信號通路存在交互作用,可能參與調控細胞增殖、侵襲和轉移。STK33的生物學意義在于其在腫瘤細胞的增殖、侵襲與轉移等過程中的重要作用,尤其在KRAS突變相關的腫瘤中,STK33的表達與腫瘤細胞的生物學行為密切相關。因此,STK33被認為是多種癌癥治療的潛在靶點。
熱銷產品
STK33 Recombinant Monoclonal Antibody (CSB-RA207790A0HU)
驗證數據

IHC image of CSB-RA207790A0HU diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
STK33 Antibodies
STK33 for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA022848GA01HU | STK33 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA287139 | STK33 Antibody | Human | ELISA,WB |
CSB-PA004188 | STK33 Antibody | Human | WB, IHC, ELISA |
CSB-PA108943 | STK33 Antibody | Human | ELISA,IHC |
CSB-PA291750 | STK33 Antibody | Human | ELISA,IHC |
CSB-PA861179LA01HU | STK33 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
CSB-PA861179LD01HU | STK33 Antibody, Biotin conjugated | Human | ELISA |
CSB-PA861179LB01HU | STK33 Antibody, HRP conjugated | Human | ELISA |
CSB-RA207790A0HU | STK33 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
STK33 Proteins
STK33 Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP861179HU CSB-EP861179HU CSB-BP861179HU CSB-MP861179HU CSB-EP861179HU-B |
Recombinant Human Serine/threonine-protein kinase 33 (STK33) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |