SRC

SRC，即肉瘤病毒蛋白Src，別名c-Src、p60-Src等。它是一種非受體酪氨酸激酶，屬于Src家族蛋白酪氨酸激酶成員，由人體細胞自身的SRC基因編碼。SRC在多種細胞類型中都有表達，尤其在淋巴細胞和成骨細胞中表達較高。SRC的作用機制主要通過其激酶活性參與調節細胞內的信號傳導，它能夠磷酸化多種蛋白質的酪氨酸殘基，從而激活或抑制這些蛋白質的功能。SRC的活性受到多種因素的調控，包括磷酸化、去磷酸化、寡聚化和與膜的結合等。SRC在生物學上的意義非常廣泛，它參與了細胞的多種生理過程，包括細胞增殖、分化、遷移、黏附和凋亡等。SRC通過激活下游的多種信號通路，如MAPK、PI3K/AKT、JAK/STAT等，對細胞的生存和功能發揮重要作用。此外，SRC的功能異常與多種疾病的發生發展有關，尤其是與腫瘤的發生、發展和轉移密切相關。在腫瘤細胞中，SRC的過度活化可以促進腫瘤細胞的增殖和侵襲，使其成為腫瘤治療中的一個潛在靶點。因此，針對SRC的小分子抑制劑正在被開發用于治療某些類型的癌癥。

熱銷產品

Recombinant Human Proto-oncogene tyrosine-protein kinase Src (SRC) (CSB-EP022650HU)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SRC Recombinant Monoclonal Antibody (CSB-RA022650A0HU)

驗證數據

Western Blot
Positive WB detected in: NIH/3T3 whole cell lysate, MCF-7 whole cell lysate
All lanes: SRC antibody at 1.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 60, 61 KDa
Observed band size: 60, 61 KDa

Immunofluorescence staining of MCF-7 cells with CSB-RA022650A0HU at 1:39, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).

Overlay histogram showing SH-SY5Y cells stained with CSB-RA022650A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then permeabilized with 0.3% Triton X-100 for 2 min. The cells were then incubated in 1x PBS /10% normal goat serum to block non-specific protein-protein interactions followed by primary antibody for 1 h at 4℃. The secondary antibody used was FITC goat anti-rabbit IgG (H+L) at 1/200 dilution for 1 h at 4℃. Control antibody (green line) was used under the same conditions. Acquisition of >10,000 events was performed.

Human Proto-oncogene tyrosine-protein kinase Src(SRC) ELISA kit (CSB-EL022650HU)

驗證數據

貨號：CSB-EL022650HU

規格：96T/48T

靈敏度：6.25 pg/mL

檢測范圍：25 pg/mL-1600 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

SRC Antibody

SRC Protein

SRC ELISA Kit

SRC Antibodies

SRC for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA022650GA01HU	SRC Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IP,IF
CSB-PA954497	Phospho-SRC (Tyr529) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA829908	SRC (Ab-529) Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA014991	Phospho-SRC (Tyr418) Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA928286	Phospho-SRC (Ser75) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA000506	Phospho-SRC (Y529) Antibody	Human,Mouse,Rat,Monkey	WB, IHC, ELISA
CSB-PA000637	Phospho-SRC (Y419) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA001803	SRC Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA001806	SRC Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA001807	SRC Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA001809	SRC Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA050132	Phospho-SRC (Y216) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA050133	Phospho-SRC (S75) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA050134	SRC Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA081645	SRC Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA080378	SRC Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-RA022650A0HU	SRC Recombinant Monoclonal Antibody	Human, Mouse	ELISA, WB, IF, FC
CSB-PA022650LA01HU	SRC Antibody	Human	ELISA, WB, IHC
CSB-PA022650LB01HU	SRC Antibody, HRP conjugated	Human	ELISA
CSB-PA022650LC01HU	SRC Antibody, FITC conjugated	Human
CSB-PA022650LD01HU	SRC Antibody, Biotin conjugated	Human	ELISA
CSB-PA022650LA11HU	SRC Antibody	Human	ELISA, IHC
CSB-PA022650LB11HU	SRC Antibody, HRP conjugated	Human	ELISA
CSB-PA022650LC11HU	SRC Antibody, FITC conjugated	Human
CSB-PA022650LD11HU	SRC Antibody, Biotin conjugated	Human	ELISA

SRC for Danio rerio (Zebrafish) (Brachydanio rerio)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA24479A0Rb	src Antibody	Zebrafish	ELISA, WB
CSB-PA24479B0Rb	src Antibody, HRP conjugated	Zebrafish	ELISA
CSB-PA24479C0Rb	src Antibody, FITC conjugated	Zebrafish
CSB-PA24479D0Rb	src Antibody, Biotin conjugated	Zebrafish	ELISA

SRC Proteins

SRC Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP022650HU CSB-BP022650HU CSB-MP022650HU CSB-EP022650HU-B	Recombinant Human Proto-oncogene tyrosine-protein kinase Src (SRC)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP022650HU	Recombinant Human Proto-oncogene tyrosine-protein kinase Src (SRC)	E.coli
CSB-EP022650HUe1	Recombinant Human Proto-oncogene tyrosine-protein kinase Src (SRC)	E.coli

SRC Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP022650MO CSB-EP022650MO CSB-BP022650MO CSB-MP022650MO CSB-EP022650MO-B	Recombinant Mouse Neuronal proto-oncogene tyrosine-protein kinase Src (Src)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SRC Proteins for Gallus gallus (Chicken)

產品貨號	產品名稱	來源
CSB-YP022650CH CSB-EP022650CH CSB-BP022650CH CSB-MP022650CH CSB-EP022650CH-B	Recombinant Chicken Proto-oncogene tyrosine-protein kinase Src (SRC), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SRC Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP894363RA CSB-EP894363RA CSB-BP894363RA CSB-MP894363RA CSB-EP894363RA-B	Recombinant Rat Proto-oncogene tyrosine-protein kinase Src (Src)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli