SMARCA5
SMARCA5，即SWI/SNF相關(guān)矩陣相關(guān)作用蛋白A5，也稱為SNF2L、BAF170或hBRM。它是一種由SMARCA5基因編碼的蛋白質(zhì)，屬于SWI/SNF染色質(zhì)重塑復(fù)合體的成員。SMARCA5在細(xì)胞核中發(fā)揮作用，其作用機(jī)制涉及利用ATP水解的能量，改變?nèi)旧|(zhì)結(jié)構(gòu)，從而調(diào)節(jié)基因的轉(zhuǎn)錄。它通過滑動(dòng)或重構(gòu)核小體位置，增加或減少轉(zhuǎn)錄因子對(duì)DNA的訪問性。SMARCA5參與的信號(hào)通路包括多種細(xì)胞周期調(diào)控、細(xì)胞增殖、分化和DNA損傷響應(yīng)等過程。在生物學(xué)意義上，SMARCA5對(duì)維持基因組穩(wěn)定性、調(diào)控細(xì)胞命運(yùn)和參與發(fā)育過程至關(guān)重要。它的異常表達(dá)或功能喪失與多種腫瘤的發(fā)生發(fā)展有關(guān)，尤其在某些類型的癌癥中，SMARCA5的突變與腫瘤的侵襲性和預(yù)后密切相關(guān)，使其成為癌癥研究和治療的潛在靶點(diǎn)。
熱銷產(chǎn)品
SMARCA5 Antibody (CSB-PA150330)
驗(yàn)證數(shù)據(jù)
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Hepg2 cells, MCF7 cells, Jurkat cells, hela cells, A431 cells, K562 cells, lncap cells, Primary antibody: CSB-PA150330(SMARCA5 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
SMARCA5 Antibodies
SMARCA5 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA021802GA01HU | SMARCA5 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA150330 | SMARCA5 Antibody | Human,Mouse | ELISA,WB |
SMARCA5 Proteins
SMARCA5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP021802HU CSB-EP021802HU CSB-BP021802HU CSB-MP021802HU CSB-EP021802HU-B |
Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
