SLC1A5
SLC1A5全稱為溶質載體家族1成員5，又稱ASCT2或ATB0，是一種中性氨基酸轉運蛋白，主要負責谷氨酰胺、丙氨酸等氨基酸的跨膜運輸。SLC1A5在腫瘤細胞中異常高表達，尤其在依賴谷氨酰胺代謝的癌細胞中，通過維持細胞內氨基酸平衡和能量供應，促進腫瘤生長與增殖。SLC1A5活性與mTOR、Ras等調控細胞代謝與增殖的分子網絡密切相關，在乳腺癌、肺癌、結直腸癌等多種惡性腫瘤中均觀察到表達水平升高。近年來，針對SLC1A5的抑制劑開發成為抗癌藥物研究熱點，例如小分子化合物V-9302已進入臨床前研究階段，通過阻斷谷氨酰胺攝取誘導癌細胞凋亡。SLC1A5還與神經退行性疾病存在潛在關聯，阿爾茨海默病患者腦脊液中ASCT2水平變化提示其可能參與神經元代謝異常過程。當前研究正探索將該蛋白作為生物標志物或聯合治療靶點的可能性。
熱銷產品
SLC1A5 Recombinant Monoclonal Antibody (CSB-RA620892MA1HU)
驗證數據
Immunofluorescence staining of MCF cell with CSB-RA620892MA1HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Human IgG(H+L).
Immunofluorescence staining of Hela cell with CSB-RA620892MA1HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Human IgG(H+L).
Overlay Peak curve showing A549 cells stained with CSB-RA620892MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
SLC1A5 Antibodies
SLC1A5 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA997190 | SLC1A5 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA620892DSR1HU | SLC1A5 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA620892DSR2HU | SLC1A5 Antibody | Human | ELISA, IHC |
| CSB-RA620892MA1HU | SLC1A5 Recombinant Monoclonal Antibody | Human | ELISA, IF, FC |
SLC1A5 Proteins
SLC1A5 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP620892HU CSB-EP620892HU CSB-BP620892HU CSB-MP620892HU CSB-EP620892HU-B |
Recombinant Human Neutral amino acid transporter B (0) (SLC1A5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
