SLAMF6
SLAMF6，全稱為信號淋巴細胞激活分子6（SLAM family member 6），也被稱為NTB-A或CD352，屬于SLAM家族成員。該蛋白是一種單程I型膜蛋白，主要由細胞外結構域、跨膜區和胞質區組成。SLAMF6 蛋白廣泛分布于免疫細胞表面，如T細胞、B細胞、NK細胞和樹突狀細胞等，并在免疫細胞的活化、分化和粘附中發揮重要作用。SLAMF6 蛋白通過與同源或異源分子相互作用，調節免疫細胞的激活和分化，影響先天性和適應性免疫反應。此外，SLAMF6 蛋白還參與多種免疫調節過程，如細胞因子分泌、細胞增殖和細胞凋亡等。SLAMF6 蛋白與多種疾病相關，包括癌癥、自身免疫性疾病和感染性疾病等。目前，針對SLAMF6 蛋白的藥物研發尚處于起步階段，但已有研究表明，靶向SLAMF6 蛋白的抗體和藥物可能成為治療癌癥和自身免疫性疾病的新策略。
熱銷產品
Recombinant Human SLAM family member 6 (SLAMF6), partial (CSB-MP021368HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The purity of SLAMF6 was greater than 90% as determined by SEC-HPLC
SLAMF6 Antibody (CSB-PA021368LA01HU)
驗證數據
Western Blot
Positive WB detected in: Hela whole cell lysate, HL60 whole cell lysate, 293T whole cell lysate, A549 whole cell lysate, Mouse kidney tissue
All lanes: SLAMF6 antibody at 5.1μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 38, 25 kDa
Observed band size: 60 kDa
IHC image of CSB-PA021368LA01HU diluted at 1:200 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of HepG2 cells with CSB-PA021368LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
SLAMF6 Antibodies
SLAMF6 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA021368LA01HU | SLAMF6 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA021368LB01HU | SLAMF6 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA021368LC01HU | SLAMF6 Antibody, FITC conjugated | Human | |
| CSB-PA021368LD01HU | SLAMF6 Antibody, Biotin conjugated | Human | ELISA |
SLAMF6 Proteins
SLAMF6 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP021368HU CSB-BP021368HU CSB-EP021368HU-B |
Recombinant Human SLAM family member 6 (SLAMF6), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP021368HU | Recombinant Human SLAM family member 6 (SLAMF6), partial | E.coli |
| CSB-MP021368HU | Recombinant Human SLAM family member 6 (SLAMF6), partial | Mammalian cell |
