SKOR2
SKOR2,全稱(chēng)為Spermidine/Spermine N1-Acetyltransferase,常見(jiàn)別名包括SAT1和SMNAT1。該蛋白主要參與多胺代謝,通過(guò)將精胺和亞精胺轉(zhuǎn)化為N1-乙酰精胺和N1-乙酰亞精胺,調(diào)節(jié)細(xì)胞內(nèi)多胺水平,進(jìn)而影響細(xì)胞增殖、凋亡和DNA修復(fù)等過(guò)程。SKOR2在多種癌癥中表達(dá)異常,與腫瘤細(xì)胞的生長(zhǎng)、轉(zhuǎn)移和耐藥性密切相關(guān)。研究表明,SKOR2的高表達(dá)與乳腺癌、前列腺癌、肺癌等惡性腫瘤的發(fā)生發(fā)展有關(guān),可作為潛在的腫瘤治療靶點(diǎn)。近年來(lái),針對(duì)SKOR2的藥物研發(fā)取得了一定進(jìn)展,例如阿斯利康的Truqap(卡匹色替)作為AKT抑制劑,在乳腺癌和前列腺癌的治療中展現(xiàn)出顯著療效。此外,科倫博泰的SKB264作為T(mén)rop2 ADC藥物,也在三陰性乳腺癌和非小細(xì)胞肺癌的治療中取得了突破性進(jìn)展。這些研究成果為SKOR2相關(guān)信號(hào)通路和疾病的治療提供了新的思路和策略。
熱銷(xiāo)產(chǎn)品
SKOR2 Antibody (CSB-PA009018PA01HU)
驗(yàn)證數(shù)據(jù)

IHC image of CSB-PA009018PA01HU diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA009018PA01HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of K562 cells with CSB-PA009018PA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
SKOR2 Antibodies
SKOR2 for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
---|---|---|---|
CSB-PA009018PA01HU | SKOR2 Antibody | Human | ELISA, IHC, IF |
CSB-PA009018PB01HU | SKOR2 Antibody, HRP conjugated | Human | ELISA |
CSB-PA009018PD01HU | SKOR2 Antibody, Biotin conjugated | Human | ELISA |
SKOR2 Proteins
SKOR2 Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
---|---|---|
CSB-YP649674HU CSB-EP649674HU CSB-BP649674HU CSB-MP649674HU CSB-EP649674HU-B |
Recombinant Human SKI family transcriptional corepressor 2 (SKOR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |