SIRT1

SIRT1，即細(xì)胞衰老相關(guān)蛋白1，別名Sirtuin 1、NAD依賴性去乙酰化酶1等。SIRT1是一種由SIRT1基因編碼的蛋白質(zhì)，屬于Sirtuin家族成員之一，主要在細(xì)胞核中發(fā)揮作用。它是一種依賴于煙酰胺腺嘌呤二核苷酸（NAD+）的去乙酰化酶，通過去除蛋白質(zhì)上的乙酰基團(tuán)來調(diào)控多種細(xì)胞過程，包括細(xì)胞代謝、應(yīng)激反應(yīng)、細(xì)胞周期和衰老。SIRT1的作用機(jī)制涉及到對多種底物蛋白的去乙酰化修飾，這些底物包括但不限于組蛋白、轉(zhuǎn)錄因子、DNA修復(fù)蛋白和信號傳導(dǎo)分子。SIRT1在生物學(xué)上的意義非常廣泛，它參與調(diào)節(jié)多種細(xì)胞生理過程和代謝途徑。SIRT1通過去乙酰化作用參與調(diào)控細(xì)胞的能量代謝，促進(jìn)細(xì)胞對應(yīng)激的適應(yīng)性，保護(hù)細(xì)胞免受氧化損傷。此外，SIRT1還參與調(diào)節(jié)細(xì)胞周期和細(xì)胞衰老過程，影響細(xì)胞的增殖和分化。SIRT1的功能異常與多種疾病的發(fā)生發(fā)展有關(guān)，包括代謝性疾病、神經(jīng)退行性疾病、心血管疾病和癌癥。因此，SIRT1是藥物開發(fā)和疾病治療中的一個潛在靶點，其激動劑和抑制劑的研究正在積極進(jìn)行中。

熱銷產(chǎn)品

Recombinant Human NAD-dependent protein deacetylase sirtuin-1 (SIRT1) (CSB-EP822202HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SIRT1 Recombinant Monoclonal Antibody (CSB-RA556800A0HU)

驗證數(shù)據(jù)

IHC image of CSB-RA556800A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Immunofluorescence staining of Hela Cells with CSB-RA556800A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

SIRT1 Antibody

SIRT1 Protein

SIRT1 ELISA Kit

SIRT1 Antibodies

SIRT1 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA021339GA01HU	SIRT1 Antibody	Human, Mouse	ELISA, WB, IHC, IF, IP
CSB-PA857953	Phospho-SIRT1 (Ser47) Antibody	Human,Mouse	ELISA,WB
CSB-PA004095	SIRT1 Antibody	Human,Mouse	WB, IHC, ELISA
CSB-PA008366	Phospho-SIRT1 (S47) Antibody	Human,Mouse	WB, ELISA
CSB-PA252235	SIRT1 Antibody	Human,Mouse	ELISA,WB
CSB-PA822202HA01HU	SIRT1 Antibody	Human	ELISA, IHC, IF
CSB-PA822202HB01HU	SIRT1 Antibody, HRP conjugated	Human	ELISA
CSB-PA822202HC01HU	SIRT1 Antibody, FITC conjugated	Human
CSB-PA822202HD01HU	SIRT1 Antibody, Biotin conjugated	Human	ELISA
CSB-RA556800A0HU	SIRT1 Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF

SIRT1 Proteins

SIRT1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP822202HU CSB-BP822202HU CSB-EP822202HU-B	Recombinant Human NAD-dependent protein deacetylase sirtuin-1 (SIRT1)	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-EP822202HU	Recombinant Human NAD-dependent protein deacetylase sirtuin-1 (SIRT1)	E.coli
CSB-EP822202HUc7	Recombinant Human NAD-dependent protein deacetylase sirtuin-1 (SIRT1)	E.coli
CSB-MP822202HU	Recombinant Human NAD-dependent protein deacetylase sirtuin-1 (SIRT1)	Mammalian cell

SIRT1 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP846058MO CSB-EP846058MO CSB-BP846058MO CSB-MP846058MO CSB-EP846058MO-B	Recombinant Mouse NAD-dependent protein deacetylase sirtuin-1 (Sirt1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SIRT1 ELISA Kit

SIRT1 ELISA Kit for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	樣本類型	靈敏度
CSB-E16187m	Mouse NAD-dependent deacetylase sirtuin-1(Sirt1)ELISA Kit	serum, plasma, tissue homogenates	0.039 ng/mL

SIRT1 ELISA Kit for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	樣本類型	靈敏度
CSB-E15058h	Human NAD-dependent deacetylase sirtuin-1 (SIRT1/SIR2L1) ELISA kit	serum, plasma, cell culture supernates, tissue homogenates	0.039 ng/mL
CSB-E15058h-IS	Human NAD-dependent deacetylase sirtuin-1 (SIRT1/SIR2L1) ELISA kit	serum, plasma, cell culture supernates, tissue homogenates	0.156 ng/mL