SHARPIN
Sharpin is a protein in humans that is encoded by SHARPIN gene. Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
SHARPIN Antibodies
SHARPIN for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA021250GA01HU | SHARPIN Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA867119LA01HU | SHARPIN Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA867119LB01HU | SHARPIN Antibody, HRP conjugated | Human | ELISA |
| CSB-PA867119LC01HU | SHARPIN Antibody, FITC conjugated | Human | |
| CSB-PA867119LD01HU | SHARPIN Antibody, Biotin conjugated | Human | ELISA |
SHARPIN Proteins
SHARPIN Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP021250BO CSB-EP021250BO CSB-BP021250BO CSB-MP021250BO CSB-EP021250BO-B |
Recombinant Bovine Sharpin (SHARPIN) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SHARPIN Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP845983MO CSB-EP845983MO CSB-BP845983MO CSB-MP845983MO CSB-EP845983MO-B |
Recombinant Mouse Sharpin (Sharpin) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SHARPIN Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP867119HU CSB-BP867119HU CSB-MP867119HU CSB-EP867119HU-B |
Recombinant Human Sharpin (SHARPIN) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP867119HU | Recombinant Human Sharpin (SHARPIN) | E.coli |
SHARPIN Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP872118RA CSB-BP872118RA CSB-MP872118RA CSB-EP872118RA-B |
Recombinant Rat Sharpin (Sharpin) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
