SFRP2
SFRP2，全稱為分泌型卷曲相關(guān)蛋白2（Secreted Frizzled-related protein 2），是一種可溶性蛋白質(zhì)，屬于SFRPs蛋白家族成員。該蛋白含有與Frizzled蛋白Wnt結(jié)合位點(diǎn)同源的富含半胱氨酸的結(jié)構(gòu)域，通過與Wnt蛋白結(jié)合，抑制Wnt信號通路，在生物發(fā)育、細(xì)胞遷移、腫瘤形成及細(xì)胞凋亡等生命過程中發(fā)揮重要作用。SFRP2蛋白還可以抑制RANKL的活性，從而抑制破骨細(xì)胞活性，并與Tolloid金屬蛋白酶結(jié)合來調(diào)節(jié)膠原形成，或者與integrin和fibronectin復(fù)合體相互作用調(diào)控細(xì)胞凋亡。研究表明，SFRP2蛋白在間充質(zhì)干細(xì)胞的自我更新過程中起著重要調(diào)節(jié)作用，并且可以增強(qiáng)骨髓間充質(zhì)干細(xì)胞心肌修復(fù)效果。此外，SFRP2蛋白的表達(dá)與大腸癌、乳腺癌等多種腫瘤的發(fā)生發(fā)展密切相關(guān)，因此，針對SFRP2蛋白的藥物研發(fā)成為近年來研究熱點(diǎn)。例如，上海銳翌生物科技有限公司自主研發(fā)的人類SFRP2和SDC2基因甲基化聯(lián)合檢測試劑盒（熒光PCR法），經(jīng)國家藥品監(jiān)督管理局批準(zhǔn)，獲得三類醫(yī)療器械注冊證，可用于結(jié)直腸癌的早期診斷。
熱銷產(chǎn)品
Recombinant Human Secreted frizzled-related protein 2 (SFRP2), partial (CSB-EP021139HU1)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
SFRP2 Antibody (CSB-PA021139LA01HU)
驗證數(shù)據(jù)
Immunofluorescent analysis of Hela cells using CSB-PA021139LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human Secreted frizzled-related protein 2(SFRP2) ELISA kit (CSB-EL021139HU)
驗證數(shù)據(jù)
貨號：CSB-EL021139HU
規(guī)格：96T/48T
靈敏度：0.039 ng/mL
檢測范圍：0.156 ng/mL-10 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
SFRP2 Antibodies
SFRP2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA021139GA01HU | SFRP2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA002583 | SFRP2 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA021139LA01HU | SFRP2 Antibody | Human | ELISA, IF |
| CSB-PA021139LB01HU | SFRP2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA021139LC01HU | SFRP2 Antibody, FITC conjugated | Human | |
| CSB-PA021139LD01HU | SFRP2 Antibody, Biotin conjugated | Human | ELISA |
SFRP2 Proteins
SFRP2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP021139MO CSB-EP021139MO CSB-BP021139MO CSB-MP021139MO CSB-EP021139MO-B |
Recombinant Mouse Secreted frizzled-related protein 2 (Sfrp2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SFRP2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP021139DO CSB-EP021139DO CSB-BP021139DO CSB-MP021139DO CSB-EP021139DO-B |
Recombinant Dog Secreted frizzled-related protein 2 (SFRP2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SFRP2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP021139HU CSB-EP021139HU CSB-BP021139HU CSB-MP021139HU CSB-EP021139HU-B |
Recombinant Human Secreted frizzled-related protein 2 (SFRP2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP021139HU1 | Recombinant Human Secreted frizzled-related protein 2 (SFRP2), partial | E.coli |
SFRP2 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP021139CH CSB-EP021139CH CSB-BP021139CH CSB-MP021139CH CSB-EP021139CH-B |
Recombinant Chicken Secreted frizzled-related protein 2 (SFRP2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SFRP2 ELISA Kit
SFRP2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL021139HU | Human Secreted frizzled-related protein 2(SFRP2) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates, cell lysates | 0.039 ng/mL |
