SETD2
Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction. Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR). Acts as a tumor suppressor. H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A.
SETD2 Antibodies
SETD2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA028785 | SETD2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA458397 | SETD2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA871619XA01phHU | SETD2 Antibody | Human | ELISA |
SETD2 Proteins
SETD2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP871619HU CSB-EP871619HU CSB-BP871619HU CSB-MP871619HU CSB-EP871619HU-B |
Recombinant Human Histone-lysine N-methyltransferase SETD2 (SETD2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
