S100B
S100B ，全稱為 S100 蛋白鈣結(jié)合蛋白 B，是一種廣泛分布于細(xì)胞質(zhì)和細(xì)胞核的蛋白質(zhì)。它也被稱為 NEF、S100、S100-B、S100beta 等。S100B 蛋白能夠與多種蛋白結(jié)合，參與細(xì)胞能量代謝、骨架重排、增殖和分化等過程，并在正常生理濃度下對(duì)神經(jīng)元具有營養(yǎng)作用。然而，當(dāng) S100B 蛋白濃度升高時(shí)，它會(huì)通過誘導(dǎo)一氧化氮合酶的活性促使一氧化氮釋放，激活小膠質(zhì)細(xì)胞及星形膠質(zhì)細(xì)胞，從而引發(fā)神經(jīng)炎癥和損傷。S100B 蛋白在缺血性腦卒中、腦出血及蛛網(wǎng)膜下腔出血等腦血管疾病中均會(huì)有不同程度地升高，其升高程度與腦神經(jīng)功能缺損、梗死面積、血腫體積及預(yù)后相關(guān)。因此，檢測血清及腦脊液中 S100B 蛋白的濃度可以反映腦組織損傷的嚴(yán)重程度，也能反映血腦屏障的完整性，在腦血管疾病的診斷和預(yù)后評(píng)估中具有重要作用。目前，針對(duì) S100B 蛋白的藥物研發(fā)尚處于早期階段，但已有研究表明，抑制 S100B 蛋白可以減輕神經(jīng)炎癥和損傷，為腦血管疾病的治療提供了新的思路。
熱銷產(chǎn)品
S100B Antibody (CSB-PA020643ESR1HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA020643ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA020643ESR1HU at dilution of 1:100
Human Soluble protein-100B,S-100B ELISA Kit (CSB-E08065h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E08065h
規(guī)格：96T/48T
靈敏度：19.5 pg/mL
檢測范圍：78 pg/mL-5000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
S100B Antibodies
S100B for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA10677A0Rb | S100B Antibody | Human | ELISA |
| CSB-PA10677B0Rb | S100B Antibody, HRP conjugated | Human | ELISA |
| CSB-PA10677C0Rb | S100B Antibody, FITC conjugated | Human | |
| CSB-PA10677D0Rb | S100B Antibody, Biotin conjugated | Human | ELISA |
| CSB-MA106771A0m | S100B Monoclonal Antibody | Human | ELISA |
| CSB-PA020643GA01HU | S100B Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA020643ESR1HU | S100B Antibody | Human | ELISA, IHC |
| CSB-PA080270 | S100B Antibody | Human,Mouse,Rat | WB |
| CSB-PA074357 | S100B Antibody | Human,Mouse,Rat | ELISA,IHC |
S100B ELISA Kit
S100B ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08065h | Human Soluble protein-100B,S-100B ELISA Kit | serum, plasma, tissue homogenates, cerebrospinal fluid (CSF) | 19.5 pg/mL |
