S100A4
S100A4蛋白全稱為鈣結(jié)合蛋白S100A4，也被稱為轉(zhuǎn)移素或p9Ka，是一種多功能小分子蛋白。它通過(guò)與細(xì)胞內(nèi)不同靶點(diǎn)結(jié)合，影響細(xì)胞骨架動(dòng)態(tài)變化，促進(jìn)細(xì)胞運(yùn)動(dòng)及侵襲能力，尤其在腫瘤轉(zhuǎn)移過(guò)程中扮演關(guān)鍵角色。S100A4常與乳腺癌、結(jié)直腸癌等多種惡性腫瘤的侵襲性生長(zhǎng)和遠(yuǎn)端擴(kuò)散密切相關(guān)，其高表達(dá)常提示患者預(yù)后不良。此外，在肺纖維化、類風(fēng)濕性關(guān)節(jié)炎等慢性疾病中，S100A4也被發(fā)現(xiàn)參與組織異常重塑和炎癥反應(yīng)調(diào)控。
近年來(lái)研究發(fā)現(xiàn)，抑制S100A4功能可有效減緩腫瘤轉(zhuǎn)移進(jìn)程。多個(gè)研究團(tuán)隊(duì)正在開(kāi)發(fā)針對(duì)該蛋白的小分子抑制劑和單克隆抗體，其中部分化合物已在動(dòng)物模型中顯示出阻斷癌細(xì)胞遷移的效果。某些已上市藥物如二甲雙胍被發(fā)現(xiàn)具有間接調(diào)控S100A4表達(dá)的作用，這為老藥新用提供了潛在方向。學(xué)術(shù)界與制藥企業(yè)正通過(guò)結(jié)構(gòu)生物學(xué)手段解析其三維構(gòu)象，以期設(shè)計(jì)出更精準(zhǔn)的靶向治療藥物。
熱銷產(chǎn)品
Recombinant Human Protein S100-A4 (S100A4) (CSB-EP020632HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
S100A4 Antibody (CSB-PA020632HA01HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: S100A4 antibody at 2µg/ml + A549 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 12 kDa
Observed band size: 12 kDa
IHC image of CSB-PA020632HA01HU diluted at 1:600 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA020632HA01HU diluted at 1:600 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
S100A4 Antibodies
S100A4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA020632HD01HU | S100A4 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA020632HC01HU | S100A4 Antibody, FITC conjugated | Human | |
| CSB-PA020632HB01HU | S100A4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA020632HA01HU | S100A4 Antibody | Human | ELISA, WB, IHC |
| CSB-PA286071 | S100A4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA443727 | S100A4 Antibody | Human | ELISA,IHC |
| CSB-PA929601 | S100A4 Antibody | Human | ELISA,WB,IHC |
S100A4 Proteins
S100A4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP020632HU CSB-BP020632HU CSB-MP020632HU CSB-EP020632HU-B |
Recombinant Human Protein S100-A4 (S100A4) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP020632HU | Recombinant Human Protein S100-A4 (S100A4) | E.coli |
S100A4 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP020632BO CSB-EP020632BO CSB-BP020632BO CSB-MP020632BO CSB-EP020632BO-B |
Recombinant Bovine Protein S100-A4 (S100A4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
S100A4 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP020632RA CSB-BP020632RA CSB-MP020632RA CSB-EP020632RA-B |
Recombinant Rat Protein S100-A4 (S100a4) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP020632RA | Recombinant Rat Protein S100-A4 (S100a4) | E.coli |
S100A4 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP020632MO CSB-EP020632MO CSB-BP020632MO CSB-MP020632MO CSB-EP020632MO-B |
Recombinant Mouse Protein S100-A4 (S100a4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
S100A4 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP883309DO CSB-EP883309DO CSB-BP883309DO CSB-MP883309DO CSB-EP883309DO-B |
Recombinant Dog Protein S100-A4 (S100A4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
S100A4 ELISA Kit
S100A4 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL020632HU | Human Protein S100-A4(S100A4) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 0.225 ng/mL |
S100A4 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL020632MO | Mouse Protein S100-A4(S100A4) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 15.6 pg/mL |
