RPRD1B
RPRD1B，全稱為Regulation of nuclear pre-mRNA domain-containing protein 1B，常見別名包括C20ORF77、RP23-396G1.1等。該蛋白參與細(xì)胞增殖的正調(diào)控，調(diào)節(jié)細(xì)胞周期過程，并增強(qiáng)RNA聚合酶II的表達(dá)。RPRD1B通過與RNA聚合酶II大亞基的磷酸化C末端結(jié)構(gòu)域結(jié)合，參與CTD的去磷酸化過程。它還能促進(jìn)RNA聚合酶II結(jié)合到CCND1啟動(dòng)子和多聚A位點(diǎn)之前的終止區(qū)域，但會(huì)減少其在多聚A位點(diǎn)之后的結(jié)合。RPRD1B還能防止RNA聚合酶II越過3'端終止位點(diǎn)，并可能允許其通過形成染色質(zhì)環(huán)回到啟動(dòng)子。此外，RPRD1B還能增強(qiáng)其他細(xì)胞周期相關(guān)基因如CDK2、CDK4、CDK6和cyclin-E的轉(zhuǎn)錄，但不影響CDKN1A、CDKN1B或cyclin-A。RPRD1B與多種疾病相關(guān)，包括腫瘤等。目前，針對(duì)RPRD1B的藥物研發(fā)尚處于早期階段，但已有研究顯示其在腫瘤治療中具有潛在的應(yīng)用價(jià)值。
熱銷產(chǎn)品
RPRD1B Antibody (CSB-PA878854HA01HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: RPRD1B antibody at 0.2μg/ml
Lane 1: Jurkat whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 37 kDa
Observed band size: 37 kDa
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA878854HA01HU at dilution of 1:100
RPRD1B Antibodies
RPRD1B for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA878854HA01HU | RPRD1B Antibody | Human | ELISA, WB, IHC |
| CSB-PA878854HD01HU | RPRD1B Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA878854HC01HU | RPRD1B Antibody, FITC conjugated | Human | |
| CSB-PA878854HB01HU | RPRD1B Antibody, HRP conjugated | Human | ELISA |
RPRD1B Proteins
RPRD1B Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP878854HU CSB-EP878854HU CSB-BP878854HU CSB-MP878854HU CSB-EP878854HU-B |
Recombinant Human Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
