RNF213

RNF213，全稱為環指蛋白213（Ring finger protein 213），是一種與多種血管相關疾病密切相關的蛋白質。該蛋白在東亞人群中是煙霧病的主要易感基因，煙霧病是一種罕見的腦血管疾病，其特征為雙側頸內動脈末端及其主要分支逐漸閉塞，同時在顱底形成異常血管網絡。RNF213蛋白還與顱內動脈閉塞或狹窄、缺血性卒中、顱內動脈瘤、腦動靜脈畸形等多種血管相關疾病有關。
RNF213蛋白具有廣泛的抗菌和抗病毒活性，可以通過泛素化脂多糖（LPS）或與ISGylated的病毒蛋白結合來對抗多種病原體。此外，RNF213蛋白還參與調節血管生成和血腦屏障的完整性。研究表明，RNF213蛋白的變異會導致腦血管異常，并導致煙霧病的發生。
目前，針對RNF213蛋白相關疾病的藥物研發尚處于早期階段。一些研究表明，抗血小板藥物可能有助于提高煙霧病患者的生存率和認知功能。此外，煙霧病的搭橋手術也是一種有效的治療方法，可以預防中風的發生。

熱銷產品

RNF213 Antibody (CSB-PA717453LA01HU)

驗證數據

IHC image of CSB-PA717453LA01HU diluted at 1:800 and staining in paraffin-embedded human gastric cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA717453LA01HU diluted at 1:800 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of A549 cells with CSB-PA717453LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

RNF213 Antibody

RNF213 Protein

RNF213 Antibodies

RNF213 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA717453LA01HU	RNF213 Antibody	Human	ELISA, IHC, IF
CSB-PA717453LB01HU	RNF213 Antibody, HRP conjugated	Human	ELISA
CSB-PA717453LC01HU	RNF213 Antibody, FITC conjugated	Human
CSB-PA717453LD01HU	RNF213 Antibody, Biotin conjugated	Human	ELISA

RNF213 Proteins

RNF213 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP717453HU CSB-EP717453HU CSB-BP717453HU CSB-MP717453HU CSB-EP717453HU-B	Recombinant Human E3 ubiquitin-protein ligase RNF213 (RNF213), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli