RIPK4
RIPK4，即受體相互作用蛋白激酶4，別名DIK、PKK。它是由人類基因組中的RIPK4基因編碼的蛋白，屬于受體相互作用蛋白激酶（RIPK）家族成員之一。RIPK4在多種細胞過程中發(fā)揮作用，包括細胞死亡、炎癥反應、皮膚分化、皮膚炎癥、皮膚傷口修復以及氧化應激和鐵死亡的調(diào)控。其作用機制涉及調(diào)節(jié)多種信號通路，如NF-κB、Wnt/β-catenin和RAF/MEK/ERK通路，以及通過影響ACSM1的表達來調(diào)節(jié)脂質(zhì)代謝，從而影響氧化應激和鐵死亡。RIPK4在調(diào)控細胞命運、維持組織穩(wěn)態(tài)、參與皮膚和腸道屏障功能以及在多種疾病中發(fā)揮重要作用，包括癌癥、急性腎損傷、神經(jīng)退行性疾病等。RIPK4的異常表達與多種疾病相關，如鱗狀細胞癌、Bartsocas-Papas綜合征等，使其成為潛在的治療靶點和預后因素。
熱銷產(chǎn)品
驗證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA436282(RIPK4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA436282(RIPK4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
RIPK4 Antibodies
RIPK4 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA436282 | RIPK4 Antibody | Human | ELISA,IHC |
| CSB-PA087089 | RIPK4 Antibody | Human | ELISA,IHC |
RIPK4 Proteins
RIPK4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP019738HU CSB-EP019738HU CSB-BP019738HU CSB-MP019738HU CSB-EP019738HU-B |
Recombinant Human Receptor-interacting serine/threonine-protein kinase 4 (RIPK4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
