RIPK3
RIPK3，全稱受體相互作用絲氨酸/蘇氨酸蛋白激酶3，是一種參與細(xì)胞死亡調(diào)控的重要蛋白。它也被稱為RIP3，屬于絲氨酸/蘇氨酸蛋白激酶家族。RIPK3在細(xì)胞死亡過程中發(fā)揮著關(guān)鍵作用，能夠激活壞死和凋亡這兩種平行的細(xì)胞死亡形式。激活的RIPK3會(huì)形成一種誘導(dǎo)壞死的復(fù)合物，并介導(dǎo)MLKL的磷酸化，促進(jìn)MLKL定位到質(zhì)膜并執(zhí)行程序性壞死，其特征是鈣內(nèi)流和質(zhì)膜損傷。此外，RIPK3還可以結(jié)合代謝酶GLUL、GLUD1和PYGL，并增強(qiáng)它們的活性，進(jìn)而增強(qiáng)ROS的產(chǎn)生。
RIPK3主要在胰腺中表達(dá)，在心臟、胎盤、肺和腎臟中檢測(cè)到表達(dá)水平較低。它在結(jié)腸癌和肺癌中表達(dá)顯著增加。RIPK3參與多種疾病的病理過程，尤其在損傷相關(guān)性疾病（如心肌梗死和缺血性腦卒中以及細(xì)胞過度增殖相關(guān)的癌癥）中發(fā)揮重要作用。目前已有多種RIPK3抑制劑被逐步研發(fā)，并已證明其在多種動(dòng)物疾病模型（如心衰、心肌缺血/再灌注和腦缺血/再灌注）中發(fā)揮保護(hù)作用，表明RIPK3有望成為治療相關(guān)疾病的潛在靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) (CSB-EP897497HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
RIPK3 Antibody (CSB-PA897497ESR1HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA897497ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA897497ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA897497ESR1HU at dilution of 1:100
Human Receptor-interacting serine/threonine-protein kinase 3(RIPK3) ELISA kit (CSB-EL019737HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL019737HU
規(guī)格：96T/48T
靈敏度：0.039 ng/ml
檢測(cè)范圍：0.156 ng/ml-10 ng/ml
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
RIPK3 Antibodies
RIPK3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA019737GA01HU | RIPK3 Antibody | Human | ELISA,WB |
| CSB-PA897497ESR1HU | RIPK3 Antibody | Human | ELISA, IHC |
| CSB-PA897497LA01HU | RIPK3 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA897497LD01HU | RIPK3 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA897497LC01HU | RIPK3 Antibody, FITC conjugated | Human | |
| CSB-PA897497LB01HU | RIPK3 Antibody, HRP conjugated | Human | ELISA |
RIPK3 Proteins
RIPK3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP886403MO | Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 3 (Ripk3) | Yeast |
| CSB-EP886403MO CSB-BP886403MO CSB-MP886403MO CSB-EP886403MO-B |
Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 3 (Ripk3) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RIPK3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP897497HU | Recombinant Human Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) | Yeast |
| CSB-EP897497HU | Recombinant Human Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) | E.coli |
| CSB-BP897497HU | Recombinant Human Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) | Baculovirus |
| CSB-MP897497HU CSB-EP897497HU-B |
Recombinant Human Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) | Mammalian cell In Vivo Biotinylation in E.coli |
RIPK3 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP897497RA | Recombinant rat Receptor-interacting serine/threonine-protein kinase 3 (Ripk3) | Baculovirus |
RIPK3 ELISA Kit
RIPK3 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL019737HU | Human Receptor-interacting serine/threonine-protein kinase 3(RIPK3) ELISA kit | serum, plasma, tissue homogenates | 0.039 ng/ml |
RIPK3 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL019737MO | Mouse Receptor-interacting serine/threonine-protein kinase 3(RIPK3) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 11.72 pg/mL |
