RGS9BP
RGS9BP,全稱為Regulator of G protein signaling 9 binding protein,常見別名有Rgs9bp。該蛋白主要在視網膜中表達,并定位于視桿外節膜。它通過與RGS9蛋白結合,穩定其結構并增強其在光感受器細胞和神經元中的功能。RGS9BP與RGS9的相互作用對于視覺信號傳遞的速度和敏感性至關重要。在視網膜中,RGS9-RGS9BP復合物通過調控轉導素(G蛋白)的活性,影響光信號傳遞的速度和敏感性。在大腦中,該復合物參與多巴胺D2受體信號通路的調控,影響運動控制和獎賞機制。RGS9BP基因突變可能導致其與RGS9結合能力下降,進而影響視覺信號處理或神經遞質調控。例如,某些突變與遲發性視網膜變性或運動障礙相關。RGS9BP過表達可能增強RGS9的穩定性,導致GPCR信號過度抑制,影響光感受器細胞反應或多巴胺信號傳遞;而表達降低可能導致RGS9降解增加,引起信號通路過度激活,與某些精神疾病或視網膜功能障礙相關。RGS9BP屬于RGS蛋白調控網絡的一部分,該網絡通過精細調控GPCR信號影響多種生理過程。
熱銷產品
RGS9BP Antibody (CSB-PA765076LA01HU)
驗證數據

Immunofluorescence staining of PC3 cells with CSB-PA765076LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
RGS9BP Antibodies
RGS9BP for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA765076LA01HU | RGS9BP Antibody | Human | ELISA, IF |
CSB-PA765076LB01HU | RGS9BP Antibody, HRP conjugated | Human | ELISA |
CSB-PA765076LC01HU | RGS9BP Antibody, FITC conjugated | Human | |
CSB-PA765076LD01HU | RGS9BP Antibody, Biotin conjugated | Human | ELISA |
RGS9BP Proteins
RGS9BP Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP765076HU CSB-EP765076HU CSB-BP765076HU CSB-MP765076HU CSB-EP765076HU-B |
Recombinant Human Regulator of G-protein signaling 9-binding protein (RGS9BP), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |