RASSF1
Ras association domain-containing protein 1is a protein in humans that is encoded by RASSF1 gene. Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.
RASSF1 Antibodies
RASSF1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA068151 | RASSF1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA729792 | RASSF1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA192001 | RASSF1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA885715LA01HU | RASSF1 Antibody | Human | ELISA, IHC |
| CSB-PA885715LB01HU | RASSF1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA885715LC01HU | RASSF1 Antibody, FITC conjugated | Human |
RASSF1 Proteins
RASSF1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP860823MO CSB-EP860823MO CSB-BP860823MO CSB-MP860823MO CSB-EP860823MO-B |
Recombinant Mouse Ras association domain-containing protein 1 (Rassf1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RASSF1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP885715HU CSB-EP885715HU CSB-BP885715HU CSB-MP885715HU CSB-EP885715HU-B |
Recombinant Human Ras association domain-containing protein 1 (RASSF1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
