PRKACA

PRKACA，cAMP-dependent protein kinase catalytic subunit alpha,別名PKCA1、Cs-PKA等。PRKACA是蛋白激酶A（PKA）的α催化亞基，PKA是一種由cAMP激活的絲氨酸/蘇氨酸蛋白激酶，由兩個催化亞基和兩個調(diào)節(jié)亞基組成。在沒有cAMP時，PKA以鈍化復(fù)合體形式存在。cAMP與調(diào)節(jié)亞基結(jié)合后，導(dǎo)致調(diào)節(jié)亞基構(gòu)象變化，使調(diào)節(jié)亞基和催化亞基解離，釋放出催化亞基，進(jìn)而使細(xì)胞內(nèi)某些蛋白的絲氨酸或蘇氨酸殘基磷酸化，改變這些蛋白的活性，影響相關(guān)基因的表達(dá)。PRKACA參與調(diào)節(jié)多種細(xì)胞功能，包括糖原、糖和脂質(zhì)的代謝，以及晝夜睡眠/覺醒周期、快速眼動睡眠等生理過程。PRKACA的異常活性與多種疾病相關(guān)，如腎上腺皮質(zhì)腺瘤、充血性心力衰竭和原發(fā)性色素性結(jié)節(jié)性腎上腺皮質(zhì)疾病。

熱銷產(chǎn)品

Recombinant Human cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) (CSB-EP018688HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PRKACA Antibody (CSB-PA018688LA01HU)

驗證數(shù)據(jù)

Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, A549 whole cell lysate
All lanes: PRKACA antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 41, 40 kDa
Observed band size: 41 kDa

IHC image of CSB-PA018688LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA018688LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

PRKACA Antibody

PRKACA Protein

PRKACA Antibodies

PRKACA for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA018688GA01HU	PRKACA Antibody	Human	ELISA,WB
CSB-PA157769	Phospho-PRKACA (Thr197) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA235804	PRKACA Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA030210	Phospho-PRKACA (S338) Antibody	Human,Mouse,Rat	IHC, ELISA
CSB-PA018688LA01HU	PRKACA Antibody	Human	ELISA, WB, IHC
CSB-PA018688LB01HU	PRKACA Antibody, HRP conjugated	Human	ELISA
CSB-PA018688LC01HU	PRKACA Antibody, FITC conjugated	Human
CSB-PA018688LD01HU	PRKACA Antibody, Biotin conjugated	Human	ELISA

PRKACA Proteins

PRKACA Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP018688HU CSB-BP018688HU CSB-MP018688HU CSB-EP018688HU-B	Recombinant Human cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP018688HU	Recombinant Human cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)	E.coli
CSB-EP018688HUe2	Recombinant Human cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)	E.coli

PRKACA Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP018688RA CSB-EP018688RA CSB-BP018688RA CSB-MP018688RA CSB-EP018688RA-B	Recombinant Rat cAMP-dependent protein kinase catalytic subunit alpha (Prkaca)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PRKACA Proteins for Sus scrofa (Pig)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP018688PI CSB-EP018688PI CSB-BP018688PI CSB-MP018688PI CSB-EP018688PI-B	Recombinant Pig cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PRKACA Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP018688MO CSB-EP018688MO CSB-BP018688MO CSB-MP018688MO CSB-EP018688MO-B	Recombinant Mouse cAMP-dependent protein kinase catalytic subunit alpha (Prkaca)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PRKACA Proteins for Bos taurus (Bovine)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP018688BO CSB-EP018688BO CSB-BP018688BO CSB-MP018688BO CSB-EP018688BO-B	Recombinant Bovine cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PRKACA Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP018688DXU CSB-EP018688DXU CSB-BP018688DXU CSB-MP018688DXU CSB-EP018688DXU-B	Recombinant Cricetulus griseus cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PRKACA Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP822648DO CSB-BP822648DO CSB-MP822648DO CSB-EP822648DO-B	Recombinant Dog cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PRKACA Proteins for Ovis aries (Sheep)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP865034SH CSB-EP865034SH CSB-BP865034SH CSB-MP865034SH CSB-EP865034SH-B	Recombinant Sheep cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli