POFUT1
POFUT1 is a protein in humans that is encoded by POFUT1 gene. Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs).
POFUT1 Antibodies
POFUT1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA018296GA01HU | POFUT1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA008381 | POFUT1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
POFUT1 Proteins
POFUT1 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018296DXU CSB-EP018296DXU CSB-BP018296DXU CSB-MP018296DXU CSB-EP018296DXU-B |
Recombinant Cricetulus griseus GDP-fucose protein O-fucosyltransferase 1 (POFUT1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
POFUT1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP715763RA CSB-EP715763RA CSB-BP715763RA CSB-MP715763RA CSB-EP715763RA-B |
Recombinant Rat GDP-fucose protein O-fucosyltransferase 1 (Pofut1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
POFUT1 Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP728616EQV CSB-EP728616EQV CSB-BP728616EQV CSB-MP728616EQV CSB-EP728616EQV-B |
Recombinant Pan troglodytes GDP-fucose protein O-fucosyltransferase 1 (POFUT1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
POFUT1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP846019MO CSB-EP846019MO CSB-BP846019MO CSB-MP846019MO CSB-EP846019MO-B |
Recombinant Mouse GDP-fucose protein O-fucosyltransferase 1 (Pofut1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
POFUT1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP862013HU CSB-EP862013HU CSB-BP862013HU CSB-MP862013HU CSB-EP862013HU-B |
Recombinant Human GDP-fucose protein O-fucosyltransferase 1 (POFUT1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
