PLA2R1
PLA2R1的中文全稱是，即磷脂酶A2受體1。別名PLA2R、PLA2-R、PLA2IR、CLEC13C、PLA2G1R。PLA2R1是一種Ⅰ型跨細胞膜受體，屬于甘露糖受體家族的成員之一。它主要分布在腎小球的足細胞膜上，在特發(fā)性膜性腎?。↖MN）中，約70%的患者體內(nèi)可檢測到針對PLA2R1的抗體，這些抗體與PLA2R1蛋白結(jié)合，影響了PLA2R1蛋白與可溶性磷脂酶A2的結(jié)合，導(dǎo)致足細胞發(fā)生病變。PLA2R1的作用機制涉及激活JAK2激酶，促進活性氧（ROS）的積累，這些活性氧誘導(dǎo)細胞死亡和衰老，從而發(fā)揮抑制腫瘤的作用。在多種癌癥中，PLA2R1的表達降低，并且已知的致癌基因如HIF2α和c-MYC可以抑制其表達。PLA2R1在白血病、腎癌和乳腺癌細胞中通過啟動子甲基化的方式被抑制，這是癌細胞中抑制腫瘤抑制基因表達的一種經(jīng)典方式。
熱銷產(chǎn)品
Recombinant Human Secretory phospholipase A2 receptor (PLA2R1), partial (CSB-BP623780HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PLA2R1 Antibody (CSB-PA623780LA01HU)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA623780LA01HU at dilution of 1:100
PLA2R1 Antibodies
PLA2R1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA623780LA01HU | PLA2R1 Antibody | Human | ELISA, IHC |
| CSB-PA623780LB01HU | PLA2R1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA623780LC01HU | PLA2R1 Antibody, FITC conjugated | Human | |
| CSB-PA623780LD01HU | PLA2R1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA623780ESR1HU | PLA2R1 Antibody | Human | ELISA, WB |
PLA2R1 Proteins
PLA2R1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP623780HU | Recombinant Human Secretory phospholipase A2 receptor (PLA2R1), partial | Yeast |
| CSB-EP623780HU | Recombinant Human Secretory phospholipase A2 receptor (PLA2R1), partial | E.coli |
| CSB-MP623780HU | Recombinant Human Secretory phospholipase A2 receptor (PLA2R1), partial | Mammalian cell |
| CSB-EP623780HU-B |
Recombinant Human Secretory phospholipase A2 receptor (PLA2R1), partial | In Vivo Biotinylation in E.coli |
| CSB-BP623780HU | Recombinant Human Secretory phospholipase A2 receptor (PLA2R1), partial | Baculovirus |
PLA2R1 ELISA Kit
PLA2R1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E13155h | Human phospholipase A2 receptor 1, 180kDa (PLA2R1) ELISA kit | serum, plasma, tissue homogenates | 0.027 ng/ml |
