PLA2G10
PLA2G10（磷脂酶A2群X）是一種磷脂酶A2家族成員，具有催化磷脂SN-2?；溗獾墓δ?，釋放出游離脂肪酸和溶血磷脂分子。它在細(xì)胞周期調(diào)控和免疫調(diào)節(jié)方面發(fā)揮作用，通過(guò)提高特定蛋白的表達(dá)水平，如在軟組織平滑肌肉瘤細(xì)胞中提高cyclin E1/CDK2的表達(dá)，促進(jìn)細(xì)胞周期進(jìn)程。在腫瘤微環(huán)境中，PLA2G10與T細(xì)胞排斥有關(guān)，其高表達(dá)可能抑制T細(xì)胞浸潤(rùn)，影響腫瘤對(duì)免疫療法的響應(yīng)。此外，PLA2G10還參與甾體激素信號(hào)通路，作為孕酮受體的靶基因，在小鼠子宮中調(diào)節(jié)子宮接受性。PLA2G10的異常表達(dá)與多種疾病包括癌癥和神經(jīng)退行性疾病相關(guān)，其抑制或阻斷可能有助于增強(qiáng)腫瘤對(duì)免疫療法的敏感性，尤其是在對(duì)傳統(tǒng)免疫檢查點(diǎn)阻斷療法響應(yīng)不佳的“冷腫瘤”中。因此，PLA2G10是一個(gè)有潛力的治療靶點(diǎn)，其研究有助于開發(fā)新的癌癥治療策略。
熱銷產(chǎn)品
Recombinant Human Group 10 secretory phospholipase A2 (PLA2G10) (CSB-EP018085HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PLA2G10 Antibodies
PLA2G10 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA018085LA01HU | PLA2G10 Antibody | Human | ELISA, IHC |
| CSB-PA018085LB01HU | PLA2G10 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA018085LC01HU | PLA2G10 Antibody, FITC conjugated | Human | |
| CSB-PA018085LD01HU | PLA2G10 Antibody, Biotin conjugated | Human | ELISA |
PLA2G10 Proteins
PLA2G10 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP018085HU CSB-BP018085HU CSB-MP018085HU CSB-EP018085HU-B |
Recombinant Human Group 10 secretory phospholipase A2 (PLA2G10) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP018085HU | Recombinant Human Group 10 secretory phospholipase A2 (PLA2G10) | E.coli |
PLA2G10 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP874149RA CSB-BP874149RA CSB-MP874149RA CSB-EP874149RA-B |
Recombinant Rat Group 10 secretory phospholipase A2 (Pla2g10) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PLA2G10 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP882554MO CSB-MP882554MO CSB-EP882554MO-B |
Recombinant Mouse Group 10 secretory phospholipase A2 (Pla2g10) | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP882554MO | Recombinant Mouse Group 10 secretory phospholipase A2 (Pla2g10) | E.coli |
| CSB-BP882554MO | Recombinant Mouse Group 10 secretory phospholipase A2 (Pla2g10) | Baculovirus |
