PIK3CG
PIK3CG，即磷脂酰肌醇-4,5-二磷酸3-激酶催化亞基γ，別名PI3Kγ、p110γ、p120-PI3K等。它是一種由PIK3CG基因編碼的蛋白質(zhì)，屬于磷脂酰肌醇3-激酶(PI3K)家族的類I催化亞基之一。PIK3CG在多種細胞類型中表達，尤其在免疫細胞中高度表達。其作用機制主要是通過與p85調(diào)節(jié)亞基結(jié)合形成PI3K復(fù)合體，進而催化磷脂酰肌醇-4,5-二磷酸(PIP2)轉(zhuǎn)化為磷脂酰肌醇-3,4,5-三磷酸(PIP3)，這一過程在細胞信號傳導中發(fā)揮關(guān)鍵作用。PIK3CG在生物學上的意義非常廣泛，它參與調(diào)節(jié)多種細胞生理過程，包括細胞生長、存活、代謝和遷移等。PIK3CG的功能異常與多種疾病有關(guān)，特別是與免疫相關(guān)疾病和癌癥的發(fā)生發(fā)展密切相關(guān)。例如，PIK3CG的突變或表達失調(diào)可能影響免疫細胞的激活和功能，進而影響炎癥反應(yīng)和自身免疫疾病。此外，PIK3CG在某些癌癥中的異常激活可能促進腫瘤細胞的增殖、侵襲和轉(zhuǎn)移。因此，PIK3CG是藥物開發(fā)和疾病治療中的一個潛在靶點。
熱銷產(chǎn)品
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PIK3CG Antibody (CSB-PA827787)
驗證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA827787(PIK3CG Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA827787(PIK3CG Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
PIK3CG Antibodies
PIK3CG for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA030057 | PIK3CG Antibody | Human | WB, IHC, ELISA |
| CSB-PA877253 | PIK3CG Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA827787 | PIK3CG Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA13309A0Rb | PIK3CG Antibody | Human | ELISA, IF |
| CSB-PA13309B0Rb | PIK3CG Antibody, HRP conjugated | Human | ELISA |
| CSB-PA13309D0Rb | PIK3CG Antibody, Biotin conjugated | Human | ELISA |
PIK3CG Proteins
PIK3CG Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018001HU CSB-BP018001HU CSB-MP018001HU CSB-EP018001HU-B |
Recombinant Human Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP018001HU | Recombinant Human Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG), partial | E.coli |
PIK3CG Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018001PI CSB-EP018001PI CSB-BP018001PI CSB-MP018001PI CSB-EP018001PI-B |
Recombinant Pig Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PIK3CG Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP878048MO CSB-EP878048MO CSB-BP878048MO CSB-MP878048MO CSB-EP878048MO-B |
Recombinant Mouse Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Pik3cg), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
