PHLPP2
PH domain leucine-rich repeat-containing protein phosphatase 2 is a protein in humans that is encoded by PHLPP2 gene. Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis.
PHLPP2 Proteins
PHLPP2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP754577HU CSB-EP754577HU CSB-BP754577HU CSB-MP754577HU CSB-EP754577HU-B |
Recombinant Human PH domain leucine-rich repeat-containing protein phosphatase 2 (PHLPP2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PHLPP2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP805359MO CSB-EP805359MO CSB-BP805359MO CSB-MP805359MO CSB-EP805359MO-B |
Recombinant Mouse PH domain leucine-rich repeat-containing protein phosphatase 2 (Phlpp2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
