PARG
PARG，即聚(ADP-核糖)糖水解酶，是一種關(guān)鍵的DNA修復(fù)酶，別名ADP riboseglycohydrolase、Poly。由PARG基因編碼，它在線(xiàn)粒體基質(zhì)中發(fā)揮作用，通過(guò)水解聚(ADP-核糖)鏈來(lái)調(diào)節(jié)細(xì)胞對(duì)DNA損傷的響應(yīng)。PARG的作用機(jī)制涉及平衡PARP酶家族催化的聚ADP-核糖化過(guò)程，對(duì)維持基因組穩(wěn)定性至關(guān)重要。PARG的生物學(xué)意義廣泛，它參與調(diào)控細(xì)胞周期、細(xì)胞死亡、DNA修復(fù)以及轉(zhuǎn)錄活性等關(guān)鍵生理過(guò)程。PARG的異常表達(dá)或功能失調(diào)與癌癥等多種疾病相關(guān)，使其成為藥物開(kāi)發(fā)和疾病治療中的潛在靶點(diǎn)，尤其在利用合成致死策略的癌癥治療中顯示出治療潛力。
熱銷(xiāo)產(chǎn)品
PARG Antibody (CSB-PA773045LA01HU)
驗(yàn)證數(shù)據(jù)
Immunofluorescent analysis of PC-3 cells using CSB-PA773045LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
PARG Antibodies
PARG for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA773045LA01HU | PARG Antibody | Human | ELISA, IF |
| CSB-PA773045LB01HU | PARG Antibody, HRP conjugated | Human | ELISA |
| CSB-PA773045LC01HU | PARG Antibody, FITC conjugated | Human | |
| CSB-PA773045LD01HU | PARG Antibody, Biotin conjugated | Human | ELISA |
PARG Proteins
PARG Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP773045HU CSB-EP773045HU CSB-BP773045HU CSB-MP773045HU CSB-EP773045HU-B |
Recombinant Human Poly (ADP-ribose) glycohydrolase (PARG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
