PAK1
PAK1，即p21活化激酶1，別名包括ADRB2、 Alpha PAK、MGC130001、p21 activated kinase 1。它是一種絲氨酸/蘇氨酸激酶，由人體細(xì)胞自身的PAK1基因編碼，屬于PAK家族成員之一。PAK1的作用機(jī)制涉及響應(yīng)小G蛋白R(shí)AC1和CDC42的信號(hào)，通過磷酸化多種底物蛋白，調(diào)控細(xì)胞的增殖、遷移、凋亡等關(guān)鍵過程。PAK1在細(xì)胞信號(hào)傳導(dǎo)、腫瘤發(fā)生、神經(jīng)發(fā)育、免疫反應(yīng)等多種生物學(xué)過程中發(fā)揮重要作用，其異?；罨c腫瘤進(jìn)展、轉(zhuǎn)移及某些神經(jīng)退行性疾病相關(guān)，是藥物開發(fā)中的潛在靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Serine/threonine-protein kinase PAK 1 (PAK1) (CSB-EP613382HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PAK1 Recombinant Monoclonal Antibody (CSB-RA287160A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: MCF7 whole cell lysate, JK whole cell lysate, K562 whole cell lysate, A549 whole cell lysate,ntera2 whole cell lysate, Mouse Heart tissue lysate, Mouse Skeletal Muscle tissue lysate, Mouse Brain tissue lysate, Rat Brain tissue lysate
All lanes: PAK1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 61 kDa
Observed band size: 61 kDa
Immunofluorescence staining of Hela cell with CSB-RA287160A0HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
PAK1 Antibodies
PAK1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA017404GA01HU | PAK1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA613382DSR1HU | PAK1 Antibody | Human | ELISA, IHC |
| CSB-PA077904 | Phospho-PAK1 (Thr212) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA861105 | PAK1 (Ab-212) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA199192 | Phospho-PAK1 (Ser199) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA294797 | Phospho-PAK1 (Ser204) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA036079 | PAK1 (Ab-199) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA900649 | PAK1 (Ab-204) Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA003703 | PAK1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA020203 | Phospho-PAK1 (T212) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA020204 | Phospho-PAK1 (S199) Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA020205 | Phospho-PAK1 (S204) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA020206 | PAK1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA020209 | PAK1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA238998 | PAK1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA116147 | PAK1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-RA287160A0HU | PAK1 Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB, IF |
PAK1 Proteins
PAK1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017404RA CSB-EP017404RA CSB-BP017404RA CSB-MP017404RA CSB-EP017404RA-B |
Recombinant Rat Serine/threonine-protein kinase PAK 1 (Pak1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PAK1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017404MO CSB-EP017404MO CSB-BP017404MO CSB-MP017404MO CSB-EP017404MO-B |
Recombinant Mouse Serine/threonine-protein kinase PAK 1 (Pak1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PAK1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP600957BO CSB-EP600957BO CSB-BP600957BO CSB-MP600957BO CSB-EP600957BO-B |
Recombinant Bovine Serine/threonine-protein kinase PAK 1 (PAK1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PAK1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP613382HU CSB-BP613382HU CSB-MP613382HU CSB-EP613382HU-B |
Recombinant Human Serine/threonine-protein kinase PAK 1 (PAK1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP613382HU | Recombinant Human Serine/threonine-protein kinase PAK 1 (PAK1) | E.coli |
