OMA1
OMA1是一種由OMA1基因表達， 不依賴于ATP的鋅離子金屬蛋白酶，有多次跨膜結構域和鋅指結合基序，位于線粒體內膜。目前說法比較一致的是，目前說法比較一致的是，OMA1可以通過調控內膜蛋白OPA1蛋白（OPA1屬于核基因，編碼的蛋白是線粒體內源發動蛋白，是線粒體塑形蛋白家族的成員，蛋白位于線粒體內膜，是調節線粒體內膜融合的重要蛋白）的水解，起到控制細胞線粒體分裂和融合的動態平衡。
OMA1目前比較公認的作用是水解OPA1蛋白。OPA1是線粒體內源發動蛋白，在許多細胞活動中起著作用，如線粒體嵴的構筑、凋亡抑制、mtDNA完整性的維持、氧化磷酸化的維持等。人體在應激反應后，蛋白酶OMA1活化會過度水解OPA1，然后促進線粒體斷裂，如果持續，則會引發體內細胞死亡和組織變性，繼而引發一系列疾病，如常染色體視神經萎縮(DOA)、巴特綜合征、神經退行性疾病和癌癥等。
熱銷產品
Recombinant Human Metalloendopeptidase OMA1, mitochondrial(OMA1) (Active) (CSB-CF856923HU)
驗證數據
Greater than 90% as determined by SDS-PAGE.
Immobilized OMA1 at 5 μg/ml can bind human BZW2, the EC50 of human BZM2 is 45.42-72.22 μg/ml.
OMA1 Antibodies
OMA1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA016332GA01HU | OMA1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA856923LA01HU | OMA1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA856923LB01HU | OMA1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA856923LC01HU | OMA1 Antibody, FITC conjugated | Human | |
| CSB-PA856923LD01HU | OMA1 Antibody, Biotin conjugated | Human | ELISA |
OMA1 Proteins
OMA1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP339648SVG1 CSB-EP339648SVG1 CSB-BP339648SVG1 CSB-MP339648SVG1 CSB-EP339648SVG1-B |
Recombinant Saccharomyces cerevisiae Mitochondrial metalloendopeptidase OMA1 (OMA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF339648SVG | Recombinant Saccharomyces cerevisiae Mitochondrial metalloendopeptidase OMA1 (OMA1) | in vitro E.coli expression system |
OMA1 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP664873BO1 CSB-EP664873BO1 CSB-BP664873BO1 CSB-MP664873BO1 CSB-EP664873BO1-B |
Recombinant Bovine Metalloendopeptidase OMA1, mitochondrial (OMA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF664873BO | Recombinant Bovine Metalloendopeptidase OMA1, mitochondrial (OMA1) | in vitro E.coli expression system |
OMA1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP856923HU1 CSB-EP856923HU1 CSB-BP856923HU1 CSB-MP856923HU1 CSB-EP856923HU1-B |
Recombinant Human Metalloendopeptidase OMA1, mitochondrial (OMA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF856923HU | Recombinant Human Metalloendopeptidase OMA1, mitochondrial (OMA1) (Active) | in vitro E.coli expression system |
| CSB-MP856923HU | Recombinant Human Metalloendopeptidase OMA1, mitochondrial (OMA1)-VLPs | Mammalian cell |
OMA1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP882230SXV1 CSB-EP882230SXV1 CSB-BP882230SXV1 CSB-MP882230SXV1 CSB-EP882230SXV1-B |
Recombinant Schizosaccharomyces pombe Mitochondrial metalloendopeptidase OMA1 (oma1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF882230SXV | Recombinant Schizosaccharomyces pombe Mitochondrial metalloendopeptidase OMA1 (oma1) | in vitro E.coli expression system |
OMA1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP887550MO1 CSB-EP887550MO1 CSB-BP887550MO1 CSB-MP887550MO1 CSB-EP887550MO1-B |
Recombinant Mouse Metalloendopeptidase OMA1, mitochondrial (Oma1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF887550MO | Recombinant Mouse Metalloendopeptidase OMA1, mitochondrial (Oma1) | in vitro E.coli expression system |
