OLR1

OLR1全稱為凝集素樣氧化低密度脂蛋白受體1，也被稱為LOX-1或SCARE1。這種蛋白主要分布在血管內(nèi)皮細胞和巨噬細胞表面，能夠特異性識別并結(jié)合氧化修飾的低密度脂蛋白顆粒，這一特性使其成為動脈粥樣硬化發(fā)生的關(guān)鍵媒介。當(dāng)血管壁受到氧化應(yīng)激或機械損傷時，LOX-1的表達顯著上調(diào)，促進脂質(zhì)沉積和單核細胞浸潤，最終導(dǎo)致血管內(nèi)膜斑塊形成。該過程與心腦血管疾病、糖尿病微血管病變等密切相關(guān)，尤其在冠心病患者的斑塊破裂事件中常觀察到LOX-1異常活躍。
LOX-1不僅參與脂質(zhì)代謝紊亂，還與腫瘤微環(huán)境中的血管新生存在關(guān)聯(lián)。針對該靶點的藥物開發(fā)集中在抑制其與配體結(jié)合的活性，已有多種單克隆抗體和小分子抑制劑進入臨床前研究階段。其中基于天然產(chǎn)物的姜黃素衍生物在動物實驗中展現(xiàn)出降低斑塊負荷的效果，而siRNA遞送技術(shù)也在探索精準(zhǔn)調(diào)控其表達的可能性。隨著精準(zhǔn)醫(yī)學(xué)的發(fā)展，針對LOX-1的檢測指標(biāo)正被納入心血管風(fēng)險評估體系，為早期干預(yù)提供新方向。

熱銷產(chǎn)品

Recombinant Human Oxidized low-density lipoprotein receptor 1 (OLR1), partial (CSB-EP016331HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

OLR1 Antibody (CSB-PA016331LA01HU)

驗證數(shù)據(jù)

Western Blot
Positive WB detected in: Rat kidney tissue
All lanes: OLR1 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 31, 21, 22 kDa
Observed band size: 31 kDa

IHC image of CSB-PA016331LA01HU diluted at 1:1200 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA016331LA01HU diluted at 1:1200 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of A549 cells with CSB-PA016331LA01HU at 1:400, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

OLR1 Antibody

OLR1 Protein

OLR1 ELISA Kit

OLR1 Antibodies

OLR1 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA016331LD01HU	OLR1 Antibody, Biotin conjugated	Human	ELISA
CSB-PA016331GA01HU	OLR1 Antibody	Human	ELISA,WB
CSB-PA016331LA01HU	OLR1 Antibody	Human, Rat	ELISA, WB, IHC, IF
CSB-PA133010	OLR1 Antibody	Human	ELISA,IHC
CSB-PA280628	OLR1 Antibody	Human	ELISA,WB,IHC
CSB-PA212407	OLR1 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA556674	OLR1 Antibody	Human	ELISA,IHC
CSB-PA187613	OLR1 Antibody	Human	ELISA,IHC

OLR1 Proteins

OLR1 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP016331BO1 CSB-EP016331BO1 CSB-BP016331BO1 CSB-MP016331BO1 CSB-EP016331BO1-B	Recombinant Bovine Oxidized low-density lipoprotein receptor 1 (OLR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF016331BO	Recombinant Bovine Oxidized low-density lipoprotein receptor 1 (OLR1)	in vitro E.coli expression system

OLR1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP016331HU CSB-BP016331HU CSB-MP016331HU CSB-EP016331HU-B	Recombinant Human Oxidized low-density lipoprotein receptor 1 (OLR1), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP016331HU	Recombinant Human Oxidized low-density lipoprotein receptor 1 (OLR1), partial	E.coli
CSB-CF016331HU	Recombinant Human Oxidized low-density lipoprotein receptor 1 (OLR1)	in vitro E.coli expression system

OLR1 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP016331RA1 CSB-EP016331RA1 CSB-BP016331RA1 CSB-MP016331RA1 CSB-EP016331RA1-B	Recombinant Rat Oxidized low-density lipoprotein receptor 1 (Olr1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF016331RA	Recombinant Rat Oxidized low-density lipoprotein receptor 1 (Olr1)	in vitro E.coli expression system

OLR1 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP872111MO CSB-EP872111MO CSB-BP872111MO CSB-MP872111MO CSB-EP872111MO-B	Recombinant Mouse Oxidized low-density lipoprotein receptor 1 (Olr1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

OLR1 Proteins for Sus scrofa (Pig)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP879995PI CSB-EP879995PI CSB-BP879995PI CSB-MP879995PI CSB-EP879995PI-B	Recombinant Pig Oxidized low-density lipoprotein receptor 1 (OLR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

OLR1 Proteins for Oryctolagus cuniculus (Rabbit)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP893616RB CSB-EP893616RB CSB-BP893616RB CSB-MP893616RB CSB-EP893616RB-B	Recombinant Rabbit Oxidized low-density lipoprotein receptor 1 (OLR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli