NTMT1
NTMT1，即蛋白質(zhì)α-N-末端甲基轉(zhuǎn)移酶1，別名NRMT1、METTL11A。這是一種在蛋白質(zhì)N末端添加甲基的轉(zhuǎn)移甲基化酶，已被確定為腫瘤發(fā)生和進展的關(guān)鍵參與者。NTMT1通過在底物α-N-末端上引入甲基，能夠調(diào)節(jié)有絲分裂、染色質(zhì)相互作用、DNA修復和維持基因組穩(wěn)定性。此外，NTMT1在多種癌癥中過表達，包括黑色素瘤、結(jié)直腸癌和宮頸癌，其表達水平與腫瘤的預后和進展有關(guān)，表明它在腫瘤發(fā)展中的重要作用。
熱銷產(chǎn)品
Recombinant Human N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) (Active) (CSB-EP880111HU1)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized CCL5 at 2 μg/ml can bind human NTMT1, the EC50 of human NTMT1 protein is 3.029-5.404 μg/ml.
驗證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA248105(NTMT1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
NTMT1 Antibodies
NTMT1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA013725GA01HU | NTMT1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA880111HA01HU | NTMT1 Antibody | Human | ELISA |
| CSB-PA248105 | NTMT1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA898702 | NTMT1 Antibody | Human,Mouse,Rat | ELISA,IHC |
NTMT1 Proteins
NTMT1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP880111HU CSB-BP880111HU CSB-MP880111HU CSB-EP880111HU-B |
Recombinant Human Alpha N-terminal protein methyltransferase 1A (METTL11A) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP880111HU | Recombinant Human Alpha N-terminal protein methyltransferase 1A (METTL11A) | E.coli |
| CSB-EP880111HU1 | Recombinant Human N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) (Active) | E.coli |
