NR2F2
NR2F2,全稱為COUP transcription factor 2,是一種轉錄因子,在哺乳動物發育過程中以高水平表達。別名包括ARP1、ARP-1、CHTD4、NF-E3、SRXX5、SVP40、COUPTF2、COUPTFB和TFCOUP2。NR2F2蛋白參與多種生理過程的調控,如甲狀腺激素、視黃酸和膽汁酸等配體的信號轉導。研究表明,NR2F2蛋白與多種疾病的發生發展密切相關,包括先天性心臟病、先天性膈疝、46,XX卵巢疾病/性發育差異等。此外,NR2F2蛋白還與發育遲緩、肌張力減退、喂養困難、小頭畸形、畸形面部特征、腎功能衰竭、聽力損失、斜視、無脾和血管畸形等表型相關。針對NR2F2蛋白的藥物研發已取得一定進展,例如,有研究開發出選擇性孤兒核受體COUP-TFII (NR2F2) 抑制劑NR2F2-IN-1,該抑制劑能有效抑制COUP-TFII驅動的NGFIA報告基因表達,為相關疾病的治療提供了新的策略。
熱銷產品
Recombinant Human Nuclear receptor subfamily 2 group F member 6 (NR2F6) (CSB-EP016058HU)
驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP016058HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) NR2F6.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP016058HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) NR2F6.
NR2F6 Antibody (CSB-PA016058LA01HU)
驗證數據

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA016058LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA016058LA01HU at dilution of 1:100
NR2F2 Antibodies
NR2F2 for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA244735 | NR2F6 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA002242 | NR2F6 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA016058LA01HU | NR2F6 Antibody | Human | ELISA, IHC |
CSB-PA016058LB01HU | NR2F6 Antibody, HRP conjugated | Human | ELISA |
CSB-PA016058LC01HU | NR2F6 Antibody, FITC conjugated | Human |
NR2F2 Proteins
NR2F2 Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP016058HU CSB-BP016058HU CSB-EP016058HU-B |
Recombinant Human Nuclear receptor subfamily 2 group F member 6 (NR2F6) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
CSB-MP016058HU | Recombinant Human Nuclear receptor subfamily 2 group F member 6 (NR2F6) | Mammalian cell |
CSB-EP016058HU | Recombinant Human Nuclear receptor subfamily 2 group F member 6 (NR2F6) | E.coli |
CSB-EP016058HUe1 | Recombinant Human Nuclear receptor subfamily 2 group F member 6 (NR2F6) | E.coli |
CSB-EP016058HUa0 | Recombinant Human Nuclear receptor subfamily 2 group F member 6 (NR2F6) | E.coli |