NLRC5
NLRC5，即核苷酸結合寡聚結構域樣受體C5，是NOD樣受體（NLR）家族中的一員，主要在免疫細胞中發揮作用。它通過感知細胞內NAD+水平的變化來調節炎癥反應，特別是在NAD+耗竭時觸發PANoptosis，一種特殊的炎癥性細胞死亡過程。NLRC5的活性對于維持免疫平衡和抵御胞內病原體至關重要，其功能異常可能與感染、炎癥和自身免疫疾病相關。此外，NLRC5還參與調控MHC I類抗原的表達，影響CD8+ T細胞的免疫應答，是免疫學研究和潛在的治療靶點。
熱銷產品
NLRC5 Antibody (CSB-PA771457LA01HU)
驗證數據
IHC image of CSB-PA771457LA01HU diluted at 1:400 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA771457LA01HU diluted at 1:400 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of Hela cells with CSB-PA771457LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
NLRC5 Antibodies
NLRC5 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA771457LA01HU | NLRC5 Antibody | Human | ELISA, IHC, IF |
| CSB-PA771457LB01HU | NLRC5 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA771457LC01HU | NLRC5 Antibody, FITC conjugated | Human | |
| CSB-PA771457LD01HU | NLRC5 Antibody, Biotin conjugated | Human | ELISA |
NLRC5 Proteins
NLRC5 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP771457HU CSB-EP771457HU CSB-BP771457HU CSB-MP771457HU CSB-EP771457HU-B |
Recombinant Human Protein NLRC5 (NLRC5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
