MRAS
MRAS全稱為肌肉RAS癌基因同源物（Muscle RAS oncogene homolog），屬于RAS超家族成員，也被稱為RAS樣蛋白12（RASL12）。這類蛋白作為細(xì)胞內(nèi)信號(hào)轉(zhuǎn)導(dǎo)的"分子開關(guān)"，通過結(jié)合GTP或GDP狀態(tài)調(diào)控下游通路，尤其在胚胎發(fā)育、細(xì)胞周期調(diào)控中扮演關(guān)鍵角色。MRAS異常激活與多種實(shí)體瘤密切相關(guān)，例如非小細(xì)胞肺癌中檢測(cè)到該基因的特異性突變位點(diǎn)，可能通過干擾細(xì)胞分化程序促進(jìn)腫瘤進(jìn)展。MRAS在心臟肥大反應(yīng)和神經(jīng)發(fā)育障礙中也顯示出調(diào)控作用，其表達(dá)異常與努南綜合征等遺傳性疾病存在關(guān)聯(lián)。
針對(duì)MRAS靶點(diǎn)的藥物開發(fā)長(zhǎng)期受限于其蛋白結(jié)構(gòu)的特殊性，傳統(tǒng)小分子抑制劑難以有效結(jié)合。但隨著KRAS G12C變構(gòu)抑制劑的成功，研究者開始探索針對(duì)MRAS特有突變（如G23V）的共價(jià)結(jié)合策略。目前已有數(shù)款候選化合物進(jìn)入臨床前研究階段，通過模擬天然蛋白構(gòu)象或阻斷效應(yīng)蛋白結(jié)合域來干預(yù)信號(hào)傳導(dǎo)。MRAS與SHOC2-PP1C復(fù)合物的特異性相互作用為開發(fā)精準(zhǔn)療法提供了新方向，相關(guān)研究成果已進(jìn)入轉(zhuǎn)化醫(yī)學(xué)驗(yàn)證階段。
熱銷產(chǎn)品
Recombinant Human Ras-related protein M-Ras (MRAS) (CSB-EP014781HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MRAS Recombinant Monoclonal Antibody (CSB-RA158563A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: MCF-7 whole cell lysate, PC3 whole cell lysate, Hela whole cell lysate, A549 whole cell lysate, HEK293 whole cell lysate
All lanes: MRAS antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 24, 16 kDa
Observed band size: 24 kDa
MRAS Antibodies
MRAS for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA014781GA01HU | MRAS Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA014781ESR1HU | MRAS Antibody | Human, Mouse | ELISA, WB |
| CSB-PA014781ESR2HU | MRAS Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA014781LA01HU | MRAS Antibody | Human | ELISA, IF |
| CSB-PA014781LD01HU | MRAS Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA014781LC01HU | MRAS Antibody, FITC conjugated | Human | |
| CSB-RA158563A0HU | MRAS Recombinant Monoclonal Antibody | Human | ELISA, WB |
| CSB-RA014781MA1HU | MRAS Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF |
MRAS Proteins
MRAS Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP014781RA CSB-EP014781RA CSB-BP014781RA CSB-MP014781RA CSB-EP014781RA-B |
Recombinant Rat Ras-related protein M-Ras (Mras) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MRAS Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP014781MO CSB-EP014781MO CSB-BP014781MO CSB-MP014781MO CSB-EP014781MO-B |
Recombinant Mouse Ras-related protein M-Ras (Mras) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MRAS Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP014781HU CSB-BP014781HU CSB-MP014781HU CSB-EP014781HU-B |
Recombinant Human Ras-related protein M-Ras (MRAS) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP014781HU | Recombinant Human Ras-related protein M-Ras (MRAS) | E.coli |
