MLH1
DNA mismatch repair protein Mlh1 is a protein in humans that is encoded by MLH1 gene. Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected.
MLH1 Antibodies
MLH1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA014624GA01HU | MLH1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA003247 | MLH1 Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA236767 | MLH1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA091025 | MLH1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA17009A0Rb | MLH1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA17009B0Rb | MLH1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA17009C0Rb | MLH1 Antibody, FITC conjugated | Human | |
| CSB-PA17009D0Rb | MLH1 Antibody, Biotin conjugated | Human | ELISA |
MLH1 Proteins
MLH1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP014624RA CSB-EP014624RA CSB-BP014624RA CSB-MP014624RA CSB-EP014624RA-B |
Recombinant Rat DNA mismatch repair protein Mlh1 (Mlh1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MLH1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP014624HU CSB-EP014624HU CSB-BP014624HU CSB-MP014624HU CSB-EP014624HU-B |
Recombinant Human DNA mismatch repair protein Mlh1 (MLH1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MLH1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP014624SVG CSB-EP014624SVG CSB-BP014624SVG CSB-MP014624SVG CSB-EP014624SVG-B |
Recombinant Saccharomyces cerevisiae DNA mismatch repair protein MLH1 (MLH1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MLH1 Proteins for Dictyostelium discoideum (Slime mold)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP700781DKK CSB-EP700781DKK CSB-BP700781DKK CSB-MP700781DKK CSB-EP700781DKK-B |
Recombinant Dictyostelium discoideum DNA mismatch repair protein Mlh1 (mlh1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MLH1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP865277SXV CSB-EP865277SXV CSB-BP865277SXV CSB-MP865277SXV CSB-EP865277SXV-B |
Recombinant Schizosaccharomyces pombe Putative MutL protein homolog 1 (mlh1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MLH1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP878086MO CSB-EP878086MO CSB-BP878086MO CSB-MP878086MO CSB-EP878086MO-B |
Recombinant Mouse DNA mismatch repair protein Mlh1 (Mlh1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
